Carboxypeptidase A6

Preferred Label : Carboxypeptidase A6;

NCIt synonyms : EC 3.4.17.-; CPA6;

NCIt definition : Carboxypeptidase A6 (437 aa, 51 kDa) is encoded by the human CPA6 gene. This protein plays a role in the maturation or metabolism of peptide hormones and neuropeptides.;

NCIt note : Carboxypeptidase A6 is a member of the peptidase M14 metallocarboxypeptidase family. The product is a preproprotein that is sequentially proteolytically processed to yield the mature enzyme, by removal of the signal peptide and then the activation peptide (involving cleavage between amino acids 129 and 130). (EntrezGene and UniProt);

NCI Metathesaurus CUI : CL1671085;

Details

Origin ID

C185843;

UMLS CUI

C3657989;

Automatic exact mappings (from CISMeF team)
- Carboxypeptidase a6 [OMIM gene]
- carboxypeptidase A6 [ORDO Gene]
- carboxypeptidase A6 [HGNC gene]
- cytochrome P450 family 2 subfamily A member 6 [ORDO Gene]
OMIM relation
- Carboxypeptidase a6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CPA6 protein, human [MeSH Supplementary Concept]
- CPA6 protein, human [MeSH concept]
gene_encodes_gene_product
- CPA6 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Peptide Metabolism [NCIt concept]
- Protein Cleavage [NCIt concept]
- Protein Degradation Process [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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