NADPH Oxidase Complex

Preferred Label : NADPH Oxidase Complex;

NCIt synonyms : Nicotinamide Adenine Dinucleotide Phosphate Oxidase; NADPH Oxidase; NADPH-Oxidase;

NCIt definition : A membrane-bound enzyme complex expressed in neutrophils or in cells of the vasculature and thyroid that faces the extracellular space and catalyzes the production of a superoxide free radical by transferring one electron to oxygen from (nicotinamide adenine dinucleotide phosphate) NADPH. In neutrophils, the superoxide is generated as part of the respiratory burst involved in immune responses.;

Details

Origin ID

C179674;

UMLS CUI

C5552912;

Automatic exact mappings (from CISMeF team)
- NAD(P)H oxidase H2O2-forming activity [GO term]
- NADPH Oxidases [MeSH Descriptor]
- NADPH Oxidases [MeSH concept]
- NADPH dehydrogenase (quinone) activity [GO term]
- NADPH oxidase complex [GO term]
- dual oxidase 1 [HGNC gene]
- dual oxidase 2 [HGNC gene]
- dual oxidase 2 [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_product_plays_role_in_biological_process
- Oxidation/Reduction [NCIt concept]
- Oxidative Burst [NCIt concept]
has_gene_product_element
- Cytochrome B-245 Heavy Chain [NCIt concept]
- Cytochrome B-245 Light Chain [NCIt concept]
- NADPH Oxidase 1 [NCIt concept]
- NADPH Oxidase 4 [NCIt concept]
- Neutrophil Cytosol Factor 1 [NCIt concept]
- Neutrophil Cytosol Factor 2 [NCIt concept]
- Neutrophil Cytosol Factor 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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