Preferred Label : NADPH Oxidases;
MeSH definition : A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH
as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety
of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH
oxidase result in GRANULOMATOUS DISEASE, CHRONIC.; A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that
catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they
are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE
DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are
expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues,
as well as GRANULOCYTES and function to transfer electrons across membranes to molecular
oxygen. Defects in the production of superoxide ions by some NADPH oxidases result
in GRANULOMATOUS DISEASE, CHRONIC.;
MeSH synonym : nad(p)h oxidase; oxidase, nadph; Oxidases, NADPH; NADPH Oxidase; Nox Proteins; NAD(P)H Oxidases;
Registry Number MeSH : EC 1.6.3.1; EC 1.6.3.-;
Is substance : O;
Origin ID : D019255;
UMLS CUI : C0068355;
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Semantic type(s)
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH
as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety
of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH
oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that
catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they
are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE
DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are
expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues,
as well as GRANULOCYTES and function to transfer electrons across membranes to molecular
oxygen. Defects in the production of superoxide ions by some NADPH oxidases result
in GRANULOMATOUS DISEASE, CHRONIC.