NADPH Oxidases

Preferred Label : NADPH Oxidases;

MeSH definition : A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.; A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.;

MeSH synonym : nad(p)h oxidase; oxidase, nadph; Oxidases, NADPH; NADPH Oxidase; Nox Proteins; NAD(P)H Oxidases;

Registry Number MeSH : EC 1.6.3.1; EC 1.6.3.-;

Is substance : O;

Details

Origin ID

D019255;

UMLS CUI

C0068355;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- NAD(P)H oxidase H2O2-forming activity [GO term]
- NADPH Oxidase Complex [NCIt concept]
- NADPH dehydrogenase (quinone) activity [GO term]
Indexing information
- 1-deaza-FAD [MeSH Supplementary Concept]
- 2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione [MeSH Supplementary Concept]
- 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine [MeSH Supplementary Concept]
- 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine [MeSH Supplementary Concept]
- 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one [MeSH Supplementary Concept]
- Duox2 protein, rat [MeSH Supplementary Concept]
- PG-L-1 compound [MeSH Supplementary Concept]
- cytochrome b245 [MeSH Supplementary Concept]
- neutrophil cytosol factor 67K [MeSH Supplementary Concept]
- oxophenylarsine [MeSH Supplementary Concept]
Record concept(s)
- NADPH Oxidases [MeSH concept]
Related MeSH Supplementary Concept(s)
- AtrbohF protein, arabidopsis [MeSH Supplementary Concept]
- CYBA protein, human [MeSH Supplementary Concept]
- CYBB protein, human [MeSH Supplementary Concept]
- Cyba protein, mouse [MeSH Supplementary Concept]
- Cyba protein, rat [MeSH Supplementary Concept]
- DUOX1 protein, human [MeSH Supplementary Concept]
- DUOX2 protein, human [MeSH Supplementary Concept]
- Duox1 protein, mouse [MeSH Supplementary Concept]
- Duox1 protein, rat [MeSH Supplementary Concept]
- NADPH-oxidase, Arabidopsis [MeSH Supplementary Concept]
- NCF2 protein, human [MeSH Supplementary Concept]
- NCF4 protein, human [MeSH Supplementary Concept]
- NOX1 protein, human [MeSH Supplementary Concept]
- NOX4 protein, human [MeSH Supplementary Concept]
- NOX5 protein, human [MeSH Supplementary Concept]
- Ncf2 protein, mouse [MeSH Supplementary Concept]
- Nox3 protein, human [MeSH Supplementary Concept]
- Nox3 protein, mouse [MeSH Supplementary Concept]
- Nox3 protein, rat [MeSH Supplementary Concept]
- Nox4 protein, mouse [MeSH Supplementary Concept]
- Nox4 protein, rat [MeSH Supplementary Concept]
- RBOHH protein, Arabidopsis [MeSH Supplementary Concept]
- RBOHJ protein, Arabidopsis [MeSH Supplementary Concept]
- RbohF protein, Arabidopsis [MeSH Supplementary Concept]
- Rhd2 protein, arabidopsis [MeSH Supplementary Concept]
- cybb protein, mouse [MeSH Supplementary Concept]
- cybb protein, rat [MeSH Supplementary Concept]
- cytochrome b558 [MeSH Supplementary Concept]
- dual oxidase Udx1, sea urchin [MeSH Supplementary Concept]
- dual oxidase, drosophila [MeSH Supplementary Concept]
- duox protein, zebrafish [MeSH Supplementary Concept]
- granulomatous disease, chronic, autosomal recessive, cytochrome B-Negative [MeSH Supplementary Concept]
- granulomatous disease, chronic, autosomal recessive, cytochrome B-Positive, type I [MeSH Supplementary Concept]
- granulomatous disease, chronic, autosomal recessive, cytochrome B-Positive, type II [MeSH Supplementary Concept]
- neutrophil cytosolic factor 1 [MeSH Supplementary Concept]
- nox protein, drosophila [MeSH Supplementary Concept]
- respiratory burst oxidase 1, tomato [MeSH Supplementary Concept]
- respiratory burst oxidase homolog D, arabidopsis [MeSH Supplementary Concept]
- superoxide-forming enzyme [MeSH Supplementary Concept]
See also
- granulomatous disease, chronic [MeSH Descriptor]
See also inter- (CISMeF)
- Setanaxib [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

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