Neutrophil Cytosol Factor 2

Preferred Label : Neutrophil Cytosol Factor 2;

NCIt synonyms : Neutrophil NADPH Oxidase Factor 2; 67 kDa Neutrophil Oxidase Factor; NCF2; NADPH Oxidase Activator 2; p67phox; NCF-2; Neutrophil Cytosolic Factor 2;

NCIt definition : Neutrophil cytosol factor 2 (526 aa, 60 kDa) is encoded by the human NCF2 gene. This protein plays a role in the generation of superoxide in neutrophils.;

NCIt note : Functions as the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils.;

Details

Origin ID

C104565;

UMLS CUI

C3538760;

Automatic exact mappings (from CISMeF team)
- Neutrophil cytosolic factor 2 [OMIM gene]
- neutrophil cytosol factor 67K [MeSH Supplementary Concept]
- neutrophil cytosolic factor 2 [ORDO Gene]
- neutrophil cytosolic factor 2 [HGNC gene]
- superoxide-generating NADPH oxidase activator activity [GO term]
OMIM relation
- Neutrophil cytosolic factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- NCF2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Phagosome [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH3 Domain [NCIt concept]
- Tetratricopeptide Repeat [NCIt concept]
gene_product_is_element_in_pathway
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
gene_product_is_physical_part_of
- NADPH Oxidase Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Antigen Processing [NCIt concept]
- Immune System Process [NCIt concept]
- Oxidative Burst [NCIt concept]
- Phagocytosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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