RNA-Binding Protein EWS

Preferred Label : RNA-Binding Protein EWS;

NCIt synonyms : EWS Protein; EWSR1 Protein; EWSR1; RNA Binding Protein EWS; EWS Oncogene; Ewing Sarcoma Breakpoint Region-1 Protein; Ewing Sarcoma Breakpoint Region 1 Protein;

NCIt definition : RNA Binding Protein EWS (656 aa, 68 kDa) is encoded by the human EWSR1 gene. This protein plays a role in RNA binding, which may repress transcription.;

NCIt note : Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor. EWS contains a transcription activation domain, but the RNA-binding domain can repress trans-activation by the activation domain. The RNA-binding activity is localized to a C-terminal RGG box. EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD polypeptide (RPB3), but not RPB5 or RPB7. EWS interacts with FAK2 and relocates from cytoplasm to ribosomes upon FAK2 activation. (SWISS-PROT);

Details

Origin ID

C17904;

UMLS CUI

C1569811;

Currated CISMeF NLP mapping
- RNA-Binding protein EWS [MeSH Descriptor]
- RNA-Binding protein EWS [MeSH concept]
OMIM relation
- Ews rna-binding protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EWSR1 protein, human [MeSH concept]
- EWSR1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EWSR1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
gene_product_is_element_in_pathway
- BARD1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Gene Regulation Process [NCIt concept]
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- RNA Transport [NCIt concept]
- RNA-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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