Metalloproteinase Inhibitor 2

Preferred Label : Metalloproteinase Inhibitor 2;

NCIt synonyms : Tissue Inhibitor of Metalloproteinases 2; Tissue Inhibitor-of Metalloproteinase-2; TIMP-2; CSC-21K;

NCIt definition : Metalloproteinase inhibitor 2 (220aa, 24 kDa) is encoded by the human TIMP2 gene. This protein plays a role in metalloproteinase inhibition.;

NCIt note : Protein_Interacts_With: MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16, MMP-19; Protein_Family: TIMP Family; Protein_Plays_Role_In_Biological_Process: Extracellular Matrix Degradation, Connective Tissue Remodeling;

Details

Origin ID

C17542;

UMLS CUI

C3178655;

Currated CISMeF NLP mapping
- tissue inhibitor of Metalloproteinase-2 [MeSH concept]
- tissue inhibitor of metalloproteinase-2 [MeSH Descriptor]
OMIM relation
- Tissue inhibitor of metalloproteinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TIMP2 protein, human [MeSH Supplementary Concept]
- TIMP2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TIMP2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Inhibition of Matrix Metalloproteinases Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Protein Degradation Inhibition [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients