Protein Tyrosine Kinase

Preferred Label : Protein Tyrosine Kinase;

NCIt synonyms : Tyrosine-Protein Kinase; PTK; Tyrosine-Specific Protein Kinase; Tyrosine Protein Kinase; Tyrosine Kinase; Protein-Tyrosine Kinase; EC 2.7.10;

NCIt definition : Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain; and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (Dictionary of Cell and Molecular Biology Online);

NCIt note : Formerly 2.7.1.112;

Details

Origin ID

C17020;

UMLS CUI

C0033681;

Biochemical function of gene products
- Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A [NCIt concept]
- FPS-FES Oncoprotein [NCIt concept]
Currated CISMeF NLP mapping
- protein-tyrosine kinase [SNOMED Notion]
False automatic mappings
- Protein-tyrosine kinase (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Protein-Tyrosine kinases [MeSH concept]
- Protein-tyrosine kinase (substance) [SNOMED CT concept]
- protein-tyrosine kinase [SNOMED Notion]
- protein-tyrosine kinases [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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