FPS-FES Oncoprotein

Preferred Label : FPS-FES Oncoprotein;

NCIt synonyms : FPS-FES Protein;

NCIt definition : Human FPS-FES Protein is a product of a mutated variant (Oncogene FPS-FES) of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. FPS-FES Protein disrupts normal cell function.;

Details

Origin ID

C18578;

UMLS CUI

C0919518;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Oncogene [NCIt concept]
- Oncogene FPS-FES [NCIt concept]
gene_product_has_biochemical_function
- Protein Tyrosine Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Tumorigenesis [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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