Oncogene FPS-FES

Preferred Label : Oncogene FPS-FES;

NCIt synonyms : FPS; FES; Fujinami Sarcoma Virus and Feline Sarcoma Virus Transforming Gene; Oncogene FES;

NCIt definition : Human Oncogene FPS-FES is a mutated variant of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. Oncogene FPS-FES disrupts normal cell function.;

GenBank Accession Number : X06292;

Details

Origin ID

C18453;

UMLS CUI

C0812383;

OMIM relation
- Fes protooncogene, tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
allele_in_chromosomal_location
- 15q26.1 [NCIt concept]
gene_encodes_gene_product
- FPS-FES Oncoprotein [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Hematopoietic Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients