Anti-Muellerian Hormone Type-2 Receptor Extracellular Domain

Preferred Label : Anti-Muellerian Hormone Type-2 Receptor Extracellular Domain;

NCIt synonyms : Anti-Mullerian Hormone Receptor II Extracellular Domain; AMHR2-ED; Extracellular Domain of Anti-Mullerian Hormone Receptor II; Anti-Müllerian Hormone Receptor II Extracellular Domain; Extracellular Domain of Anti-Müllerian Hormone Receptor II;

NCIt definition : Anti-Muellerian hormone type-2 receptor extracellular domain is encoded by the human AMHR2 gene. This protein may play a role in ovarian carcinogenesis.;

NCIt note : Since anti-Muellerian hormone type-2 receptor (AMHR2) is a type III membrane proteint, cell surface localization of the full length protein may depend on the presence of the transmembrane domain, rather than on its signal sequence. Thus AMHR2-ED may be localized to the endoplasmic reticulum rather than being secreted. (OMIM); Anti-Muellerian hormone type-2 receptor extracellular domain may be a promising anti-cancer vaccine target. (https://www.cancer.gov/news-events/cancer-currents-blog/2017/ovarian-cancer-vaccine?cid eb_govdel);

NCI Metathesaurus CUI : CL545789;

Details

Origin ID

C147927;

UMLS CUI

C4555207;

Automatic exact mappings (from CISMeF team)
- Anti-mullerian hormone type II receptor [OMIM gene]
- anti-Mullerian hormone receptor type 2 [ORDO Gene]
OMIM relation
- Anti-mullerian hormone type II receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- AMHR2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Ovary [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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