20S Proteasome

Preferred Label : 20S Proteasome;

NCIt synonyms : 20S Proteosome; 20S Core Proteasome; 20S Catalytic Proteasome; 20S Proteasome;

NCIt definition : The 20S proteasome, as proteolytic core of the proteasome system, is essential in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cell. It has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD). The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the ATP ubiquitin degradation pathway.;

Details

Origin ID

C13737;

UMLS CUI

C0208355;

Anatomic structure is physical part of
- 26S ATP-Dependent Proteasome [NCIt concept]
- Cell [NCIt concept]
Associated anatomy of gene products
- Proteasome Subunit Alpha Type-5 [NCIt concept]
Automatic exact mappings (from CISMeF team)
- proteasome core complex [GO term]
- proteasome endopeptidase complex [MeSH Descriptor]
- proteasome endopeptidase complex [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Multicatalytic endopeptidase complex (substance) [SNOMED CT concept]
- proteasome endopeptidase complex [MeSH concept]
- proteasome endopeptidase complex [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
is_target
- Carfilzomib [NCIt concept]
- Marizomib [NCIt concept]
- Oprozomib [NCIt concept]

Keyword's position in hierarchy(ies) :

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