NCIt definition : An orally bioavailable proteasome inhibitor with potential antineoplastic activity.
Proteasome inhibitor ONX 0912 inhibits the activity of the proteasome, thereby blocking
the targeted proteolysis normally performed by the proteasome; this may result in
an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling
pathways may follow, eventually leading to the induction of apoptosis and inhibition
of tumor growth. Proteasomes are large protease complexes that degrade unneeded or
damaged proteins that have been ubiquitinated.;
Automatic exact mappings (from CISMeF team)