" /> Carfilzomib - CISMeF





Preferred Label : Carfilzomib;

NCIt synonyms : (2S)-N-((1S)-1-Benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide; CFZ;

NCIt definition : An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.;

UNII : 72X6E3J5AR;

InChIKey : BLMPQMFVWMYDKT-NZTKNTHTSA-N;

CAS number : 868540-17-4;

Drug name : Kyprolis; Carfilnat;

Molecule name : PR-171; PR 171;

Chemical formula : C40H57N5O7;

Codes from synonyms : 89;

Details


Keyword's position in hierarchy(ies) : arborescence

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07/05/2025


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