Carfilzomib - CISMeF

Preferred Label : Carfilzomib;

NCIt synonyms : (2S)-N-((1S)-1-Benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide; CFZ;

NCIt definition : An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.;

UNII : 72X6E3J5AR;

InChIKey : BLMPQMFVWMYDKT-NZTKNTHTSA-N;

CAS number : 868540-17-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 868540-17-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Kyprolis; Carfilnat;

Molecule name : PR-171;

Chemical formula : C40H57N5O7;

Codes from synonyms : 89;

Details

Origin ID

C52196;

UMLS CUI

C2001856;

Automatic exact mappings (from CISMeF team)
- Carfilzomib [ICD-11 Extension code]
- carfilzomib [ATC Code]
CISMeF manual mappings
- Carfilzomib (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing carfilzomib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Carfilzomib (substance) [SNOMED CT concept]
- Product containing carfilzomib (medicinal product) [SNOMED CT concept]
- carfilzomib [ATC Code]
- carfilzomib [MeSH concept]
- carfilzomib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- 20S Proteasome [NCIt concept]
is_component_of_chemotherapy_regimen
- Bendamustine/Carfilzomib/Dexamethasone Regimen [NCIt concept]
- CCD Regimen [NCIt concept]
- CYCLONE Regimen [NCIt concept]
- CaRD Regimen [NCIt concept]
- Carfilzomib Regimen [NCIt concept]
- Carfilzomib/Daratumumab/Dexamethasone Regimen [NCIt concept]
- Carfilzomib/Dexamethasone Regimen [NCIt concept]
- Carfilzomib/Lenalidomide Regimen [NCIt concept]
- Carfilzomib/Panobinostat Regimen [NCIt concept]
- Dara-KRd Regimen [NCIt concept]
- Isa-Kd Regimen [NCIt concept]
- KCRd Regimen [NCIt concept]
- KPD Regimen [NCIt concept]
- KRd Regimen [NCIt concept]
- SKd Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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