Preferred Label : Polypodium leucotomos Extract;
NCIt synonyms : PL Extract; PLE;
NCIt definition : A nutritional supplement composed of an aqueous extract derived from the leaves of
the tropical fern belonging to the Polypodiaceae family, Polypodium leucotomos (PL;
Phlebodium aureum), with potential photoprotective, skin protective, anti-inflammatory,
immunomodulating and antioxidant activities. This extract contains many phenolic compounds,
such as ferulic, caffeic, coumaric and vanillic acid, which are mainly responsible
for this extract's effects. Upon administration, Polypodium leucotomos extract (PLE)
exerts antioxidant activity by scavenging free radicals and inhibiting the generation
and release of reactive oxygen species (ROS), thereby preventing ultraviolet (UV)-induced
as well as ROS-induced DNA damage. In addition, the chemicals in this extract protect
antioxidant enzymes and modulate expression of cancer and inflammation-related genes,
including the induction of the expression of tumor suppressor genes and the inhibition
of the expression of pro-inflammatory cytokines and inflammatory enzymes, thereby
inhibiting the activation of signal transduction pathways involved in carcinogenesis
and inflammation, respectively. PLE also stimulates tissue inhibitors of metalloproteinases
(TIMPs) and inhibits matrix metalloproteinases (MMPs).;
Drug name : Fernblock;
Origin ID : C129595;
UMLS CUI : C1614561;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
https://www.e-cancer.fr/Expertises-et-publications/Catalogue-des-publications/Traitements-systemiques-des-cancers-du-sein-localises-Cancers-de-sous-type-histologique-triple-negatif-Thesaurus
https://www.e-cancer.fr/Expertises-et-publications/Catalogue-des-publications/Traitements-systemiques-des-cancers-du-sein-localises-de-sous-type-histologique-triple-negatif-Question-clinique-1-cancers-de-stade-I-chirurgie-vs-chimiotherapie-neoadjuvante-Synthese
2024
France
practice guideline
No Treatment for Diabetes
SDHB Negative
triplets
Drug Delivery System
Device System
Hepatitis B Surface Antibody Negative
Localized
10q23/PTEN Locus Deletion Negative
Have Not Tried It
thesaurus
ETV Gene Rearrangement Negative
FGFR2 Gene Rearrangement Negative
PAS Negative
TERT Promoter Mutation Negative
Tray Dosing Unit
Systemic Immunotherapy
Thesaurus
Hepatitis B Virus Surface Antigen Negative
Lack of Expression of PD-L1
CDH1 Gene Mutation Negative
Treat
Treating
BAP1 Gene Mutation Negative
FGFR3 Gene Mutation Negative
Treatment Study
IDH Family Wildtype
breast
Locally
Drug Delivery System Category
PAX8 Gene Rearrangement Negative
On Treatment
CDKN2A-p16 Negative
HRAS Gene Mutation Negative
RET Gene Rearrangement Negative
Epstein-Barr Virus Negative
GNA11 Gene Mutation Negative
ESR2 Negative
Male Breast
vocabulary, controlled
GNAQ Gene Mutation Negative
Polypodium leucotomos Extract
During Treatment
ERG Gene Rearrangement Negative
Murine Breast
NCI Thesaurus
Therapy Object
Trait
Treatment
NRAS Gene Mutation Negative
Female Breast
Negative Number
Unmethylated MGMT Gene Promoter
ANO1 Negative
ATRX Gene Mutation Negative
BRAF Gene Mutation Negative
KIT Negative
Histologic Type
KRAS Gene Mutation Negative
Biomaterial Treatment
Human Immunodeficiency Virus Negative
Treatment Epoch
SDHA Negative
Tray
ERBB2 Gene Amplification Negative
GDC Treatment Frequency Terminology
FGFR2 Gene Mutation Negative
FGFR1 Gene Mutation Negative
Wnt Negative
Negative Charge
CTNNB1 Gene Mutation Negative
Hepatitis B Virus Core Antibody Negative
ERBB2 Gene Mutation Negative
histology
Negative Lymph Node
Progesterone Receptor Negative
FGFR3 Gene Rearrangement Negative
---
https://www.cochrane.org/fr/CD014805/BREASTCA_chimiotherapie-contenant-du-platine-pour-les-femmes-avant-ou-apres-une-intervention-chirurgicale
2023
United Kingdom
review of literature
french abstract
Negative Lymph Node
FGFR1 Gene Mutation Negative
GNA11 Gene Mutation Negative
Pharmacotherapy
ERBB2 Gene Amplification Negative
PAS Negative
Cancer Intervention
ERG Gene Rearrangement Negative
Hepatitis B Virus Core Antibody Negative
neoplasm staging
KIT Negative
women
Woman
Hepatitis B Surface Antibody Negative
platinum, nos
SDHB Negative
neoplasm, malignant
Cisplatin
ANO1 Negative
Polypodium leucotomos Extract
ERBB2 Gene Mutation Negative
platinum
Unmethylated MGMT Gene Promoter
FGFR3 Gene Mutation Negative
Lack of Expression of PD-L1
procedural approach, nos
Contain
FGFR2 Gene Mutation Negative
HRAS Gene Mutation Negative
BAP1 Gene Mutation Negative
Carboplatin
NRAS Gene Mutation Negative
operative procedure, nos
Progesterone Receptor Negative
Chemotherapy
Wnt Negative
KRAS Gene Mutation Negative
triplets
FGFR3 Gene Rearrangement Negative
CDKN2A-p16 Negative
Human Immunodeficiency Virus Negative
PAX8 Gene Rearrangement Negative
Drug Therapy
During or After
CTNNB1 Gene Mutation Negative
FGFR2 Gene Rearrangement Negative
GNAQ Gene Mutation Negative
early
RET Gene Rearrangement Negative
Status Post
Negative Number
ATRX Gene Mutation Negative
Have Not Tried It
1p/19q Codeletion Negative
ESR2 Negative
breast cancer
Surgical Procedure
Epstein-Barr Virus Negative
chemotherapy
10q23/PTEN Locus Deletion Negative
Platinum
SDHA Negative
triple negative breast neoplasms
Negative Charge
Hepatitis B Virus Surface Antigen Negative
TERT Promoter Mutation Negative
BRAF Gene Mutation Negative
Early Stage Breast Carcinoma
ETV Gene Rearrangement Negative
surgical procedures, operative
IDH Family Wildtype
chemotherapy, nos
Succimer
Platinum Eskimo
CDH1 Gene Mutation Negative
---
https://www.has-sante.fr/jcms/p_3466058/fr/amvia-sky-hf-t
2023
France
health technology assessment
cardiac pacemaker
infusion pumps, implantable
Cardiac Pacemaker
implantation of heart pacemaker
cardiac resynchronization therapy
Spectral Karyotyping
both cardiac ventricles
Polypodium leucotomos Extract
Stimulation
Chamber
Pacemaker Procedure
cardiotonic agents
Have Not Tried It
Atrio-Biventricular pacing
pacemaker, artificial
triplets
Implant
---
https://www.has-sante.fr/jcms/p_3466061/fr/amvia-sky-hf-t-qp
2023
France
health technology assessment
Cardiac Resynchronization Therapy
infusion pumps, implantable
Spectral Karyotyping
Chamber
Implant
Cardiac Pacemaker
Pacemaker Procedure
Atrio-Biventricular pacing
cardiac resynchronization therapy
biventricular pacemakers, artificial
Have Not Tried It
Polypodium leucotomos Extract
both cardiac ventricles
triplets
implantation of heart pacemaker
cardiac resynchronization therapy devices
cardiac pacemaker
---
