Preferred Label : Carboplatin;
NCIt synonyms : platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2); 1,1-cyclobutanedicarboxylic acid platinum complex; (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum; CBDCA; Carboplatino; Carboplatin Hexal; cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II); Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum; cis-diammine(cyclobutanedicarboxylato)platinum II; Paraplat; Carboplatinum;
NCIt related terms : Paraplatin;
NCIt definition : A second-generation platinum compound with a broad spectrum of antineoplastic properties.
Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl
residue. This agent is activated intracellularly to form reactive platinum complexes
that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand
and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced
DNA and protein effects result in apoptosis and cell growth inhibition. This agent
possesses tumoricidal activity similar to that of its parent compound, cisplatin,
but is more stable and less toxic. (NCI04);
Alternative definition : NCI-GLOSS: A drug that is used to treat advanced ovarian cancer that has never been
treated or symptoms of ovarian cancer that has come back after treatment with other
anticancer drugs. It is also used with other drugs to treat advanced, metastatic,
or recurrent non-small cell lung cancer and is being studied in the treatment of other
types of cancer. Paraplatin is a form of the anticancer drug cisplatin and causes
fewer side effects in patients. It attaches to DNA in cells and may kill cancer cells.
It is a type of platinum compound.;
UNII : BG3F62OND5;
InChIKey : OLESAACUTLOWQZ-UHFFFAOYSA-L;
CAS number : 41575-94-4;
Drug name : Blastocarb; Carbosin; Displata; Paraplatine; Carbosol; Novoplatinum; Platinwas; Paraplatin AQ; Ercar; Carboplat; Nealorin; Ribocarbo; Carbotec;
Molecule name : JM-8;
Chemical formula : C6H6O4.Pt.2H3N;
NSC code : 201345; 241240;
ChEBI ID : CHEBI:31355;
Codes from synonyms : CDR0000045182; NSC0241240; CDR0000635889; 88;
Origin ID : C1282;
UMLS CUI : C0079083;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
https://www.cochrane.org/fr/CD014805/BREASTCA_chimiotherapie-contenant-du-platine-pour-les-femmes-avant-ou-apres-une-intervention-chirurgicale
2023
United Kingdom
review of literature
french abstract
Negative Lymph Node
FGFR1 Gene Mutation Negative
GNA11 Gene Mutation Negative
Pharmacotherapy
ERBB2 Gene Amplification Negative
PAS Negative
Cancer Intervention
ERG Gene Rearrangement Negative
Hepatitis B Virus Core Antibody Negative
neoplasm staging
KIT Negative
women
Woman
Hepatitis B Surface Antibody Negative
platinum, nos
SDHB Negative
neoplasm, malignant
Cisplatin
ANO1 Negative
Polypodium leucotomos Extract
ERBB2 Gene Mutation Negative
platinum
Unmethylated MGMT Gene Promoter
FGFR3 Gene Mutation Negative
Lack of Expression of PD-L1
procedural approach, nos
Contain
FGFR2 Gene Mutation Negative
HRAS Gene Mutation Negative
BAP1 Gene Mutation Negative
Carboplatin
NRAS Gene Mutation Negative
operative procedure, nos
Progesterone Receptor Negative
Chemotherapy
Wnt Negative
KRAS Gene Mutation Negative
triplets
FGFR3 Gene Rearrangement Negative
CDKN2A-p16 Negative
Human Immunodeficiency Virus Negative
PAX8 Gene Rearrangement Negative
Drug Therapy
During or After
CTNNB1 Gene Mutation Negative
FGFR2 Gene Rearrangement Negative
GNAQ Gene Mutation Negative
early
RET Gene Rearrangement Negative
Status Post
Negative Number
ATRX Gene Mutation Negative
Have Not Tried It
1p/19q Codeletion Negative
ESR2 Negative
breast cancer
Surgical Procedure
Epstein-Barr Virus Negative
chemotherapy
10q23/PTEN Locus Deletion Negative
Platinum
SDHA Negative
triple negative breast neoplasms
Negative Charge
Hepatitis B Virus Surface Antigen Negative
TERT Promoter Mutation Negative
BRAF Gene Mutation Negative
Early Stage Breast Carcinoma
ETV Gene Rearrangement Negative
surgical procedures, operative
IDH Family Wildtype
chemotherapy, nos
Succimer
Platinum
CDH1 Gene Mutation Negative
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