Chromodomain-Helicase-DNA-Binding Protein 4

Preferred Label : Chromodomain-Helicase-DNA-Binding Protein 4;

NCIt synonyms : EC 3.6.4.12; ATP-Dependent Helicase CHD4; Mi-2 Autoantigen 218 kDa Protein; CHD-4; Mi2-Beta; Chromodomain Helicase DNA-Binding Protein 4; CHD4;

NCIt related terms : MI-2 BETA ANTIGEN; MI-2b; Dermatomyositis Autoantigen Mi-2 Beta; MI-2 Beta;

NCIt definition : Chromodomain-helicase-DNA-binding protein 4 (1912 aa, 218 kDa) is encoded by the human CHD4 gene. This protein is involved in chromatin remodeling.;

Alternative definition : CDISC: The 218 kDa beta isoform of the MI-2 antigen encoded by CHD4 gene, which is a helicase in the nucleosome remodeling-deacetylase complex involved in transcription regulation. It can be considered as an autoantigen and is commonly associated with the systemic autoimmune myopathy dermatomyositis.;

NCIt note : Chromodomain-helicase-DNA-binding protein 4 is part of the nucleosome remodeling and histone deacetylase (NuRD) complex and is an nuclear autoantigen in dermatomyositis.;

Details

Origin ID

C128253;

UMLS CUI

C1431547;

Automatic exact mappings (from CISMeF team)
- CD4 [LOINC component]
- CD4 Antigens [MeSH Descriptor]
- CD4 cells [LOINC component]
- Chromodomain helicase dna-binding protein 4 [OMIM gene]
OMIM relation
- Chromodomain helicase dna-binding protein 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CHD4 protein, human [MeSH Supplementary Concept]
- CHD4 protein, human [MeSH concept]
- Mi-2 beta [LOINC component]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- CHD4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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