" /> Nucleolysin TIA-1 Isoform p40 - CISMeF





Preferred Label : Nucleolysin TIA-1 Isoform p40;

NCIt synonyms : P40-TIA-1; TIA-1; RNA-Binding Protein TIA-1; T-Cell-Restricted Intracellular Antigen-1;

NCIt definition : Nucleolysin TIA-1 isoform p40 (386 aa, 43 kDa) is encoded by the human TIA1 gene. This protein is involved in RNA binding, alternative splicing, translational regulation and nucleolysis.;

NCIt note : Nucleolysin TIA-1 isoform p40 binds to to AU-rich elements (AREs) located in the 3' untranslated regions (3' UTRs) of mRNA. (UniProt); The major granule-associated species is a 15 kDa protein that is expressed in cytolytic lymphocytes (CTLs) and natural killer cells. It is thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing because no alternative promoter sites have been found. (EntrezGene);

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31/07/2025


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