Nucleolysin TIA-1 Isoform p40

Preferred Label : Nucleolysin TIA-1 Isoform p40;

NCIt synonyms : P40-TIA-1; TIA-1; RNA-Binding Protein TIA-1; T-Cell-Restricted Intracellular Antigen-1;

NCIt definition : Nucleolysin TIA-1 isoform p40 (386 aa, 43 kDa) is encoded by the human TIA1 gene. This protein is involved in RNA binding, alternative splicing, translational regulation and nucleolysis.;

NCIt note : Nucleolysin TIA-1 isoform p40 binds to to AU-rich elements (AREs) located in the 3' untranslated regions (3' UTRs) of mRNA. (UniProt); The major granule-associated species is a 15 kDa protein that is expressed in cytolytic lymphocytes (CTLs) and natural killer cells. It is thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing because no alternative promoter sites have been found. (EntrezGene);

Details

Origin ID

C127899;

UMLS CUI

C1429678;

Automatic exact mappings (from CISMeF team)
- T-Cell Intracellular Antigen-1 [MeSH Descriptor]
- TIA1 cytotoxic granule associated RNA binding protein [ORDO Gene]
- TIA1 cytotoxic granule associated RNA binding protein [HGNC gene]
- Tia1 cytotoxic granule-associated rna-binding protein [OMIM gene]
OMIM relation
- Tia1 cytotoxic granule-associated rna-binding protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- TIA1 protein, human [MeSH Supplementary Concept]
- TIA1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- TIA1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
gene_product_is_element_in_pathway
- West Nile Virus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- RNA Splicing [NCIt concept]

Keyword's position in hierarchy(ies) :

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