Neuroendocrine Convertase 1

Preferred Label : Neuroendocrine Convertase 1;

NCIt synonyms : EC 3.4.21.93; Prohormone Convertase 1; Proprotein Convertase 1; Proprotein Convertase Subtilisin/Kexin Type 1; NEC 1; PC1; Proprotein Convertase Subtilisin/Kexin-Type 1; PCSK1;

NCIt definition : Neuroendocrine convertase 1 (753 aa, 84 kDa) is encoded by the human PCSK1 gene. This protein plays a role in the proteolytic activation of protein hormones and neuropeptides.;

NCIt note : Neuroendocrine convertase 1 releases mature proteins from their proproteins through cleavage of -Lys-Arg-/Xaa bonds, where Xaa can be any amino acid. (UniProt);

Détails

Origin ID

C127854;

UMLS CUI

C3849253;

Automatic exact mappings (from CISMeF team)
- Ectonucleotide pyrophosphatase/phosphodiesterase 1 [OMIM gene]
- PC1 (body structure) [SNOMED CT concept]
- Pachyonychia congenita 1 [OMIM Phenotype]
- Proprotein convertase 1 (substance) [SNOMED CT concept]
- Proprotein convertase, subtilisin/kexin-type, 1 [OMIM gene]
- proprotein convertase 1 [MeSH concept]
- proprotein convertase 1 [MeSH Descriptor]
- proprotein convertase subtilisin/kexin type 1 [ORDO Gene]
- proprotein convertase subtilisin/kexin type 1 [HGNC gene]
OMIM relation
- Proprotein convertase, subtilisin/kexin-type, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PCSK1 protein, human [MeSH Supplementary Concept]
- PCSK1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PCSK1 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Secretory Granule [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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