Omacetaxine Mepesuccinate

Preferred Label : Omacetaxine Mepesuccinate;

NCIt synonyms : Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester); HHT;

NCIt related terms : homoharringtonine; Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI);

NCIt definition : A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types.;

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the plant alkaloid family of drugs.;

UNII : 6FG8041S5B;

InChIKey : HYFHYPWGAURHIV-JFIAXGOJSA-N;

CAS number : 26833-87-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 26833-87-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ceflatonin; Synribo; Omapro;

Molecule name : CGX-635;

Chemical formula : C29H39NO9;

NSC code : 141633;

Codes from synonyms : NSC0141633; CDR0000045216;

Details

Origin ID

C1127;

UMLS CUI

C0062941;

Currated CISMeF NLP mapping
- Homoharringtonine [MeSH Descriptor]
- Omacetaxine mepesuccinate (substance) [SNOMED CT concept]
- homoharringtonine [MeSH concept]
False automatic mappings
- Hereditary hemorrhagic telangiectasia [ORDO Disease]
See also inter- (CISMeF)
- Product containing omacetaxine mepesuccinate (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Homoharringtonine [MeSH Descriptor]
- Omacetaxine mepesuccinate (substance) [SNOMED CT concept]
- homoharringtonine [MeSH concept]
- omacetaxine mepesuccinate [ATC Code]
Validated automatic mappings to BTNT
- omacetaxine mepesuccinate [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Ribosome [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Ribosomal Function Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Omacetaxine [NCIt concept]
has_target
- Ribosome [NCIt concept]
is_component_of_chemotherapy_regimen
- Cytarabine/Homoharringtonine [NCIt concept]
- Cytarabine/Homoharringtonine/Interferon Alfa [NCIt concept]
- Homoharringtonine/Interferon Alfa [NCIt concept]
- Omacetaxine Regimen [NCIt concept]
is_salt_form_of
- Omacetaxine [NCIt concept]

Keyword's position in hierarchy(ies) :

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