Homoharringtonine

Preferred Label : Homoharringtonine;

MeSH definition : Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.;

MeSH synonym : Omacetaxine Mepesuccinate;

MeSH hyponym : Omacetaxine;

MeSH CAS label : Cephalotaxine, O3-((2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methyl-1-oxoheptyl)-;

MeSH Related Number : 24316-19-6 (Cephalotaxine); 26833-87-4 (Homoharringtonine); 84MI6OYN4Z;

UNII : 6FG8041S5B;

Details

Origin ID

D000077863;

UMLS CUI

C0062941;

ATC code(s)
- omacetaxine mepesuccinate [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Omacetaxine Mepesuccinate [NCIt concept]
- Omacetaxine mepesuccinate (substance) [SNOMED CT concept]
False automatic mappings
- Hereditary haemorrhagic telangiectasia [ICD-11 Sub-sub category]
- Hereditary haemorrhagic telangiectasia [MedDRA Preferred Term]
- Hereditary haemorrhagic telangiectasia [ICD-10 Sub-category (who)]
- Hereditary hemorrhagic telangiectasia [ICD-10 Sub-category]
- Hereditary hemorrhagic telangiectasia [MedDRA LLT]
- Hereditary hemorrhagic telangiectasia [ORDO Disease]
- Hereditary hemorrhagic telangiectasia [ICD-9 code]
- Osler hemorrhagic telangiectasia syndrome (disorder) [SNOMED CT concept]
- Osler-Rendu disease [PASCAL descriptor]
- Osler-Weber-Rendu disease [MedDRA LLT]
- Rendu Osler Weber syndrome [Disease (Nov.)]
- Rendu-Osler-Weber disease [TUV Concept]
- Rendu-Osler-Weber syndrome [MedDRA LLT]
- Telangiectasia, hereditary hemorrhagic, type 1 [OMIM Phenotype]
- hereditary hemorrhagic telangiectasia [DO Concept]
- osler hemorrhagic telangiectasia syndrome [SNOMED Notion]
MeSH indexing information
- apoptosis [MeSH Descriptor]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
Pharmacological action(s)
- antineoplastic agents, phytogenic [MeSH Descriptor]
- protein synthesis inhibitors [MeSH Descriptor]
Record concept(s)
- Homoharringtonine (3(R))-isomer [MeSH concept]
- Synribo [MeSH concept]
- ceflatonin [MeSH concept]
- cephalotaxine [MeSH concept]
- homoharringtonine [MeSH concept]
Related MeSH Supplementary Concept(s)
- homoharringtonine, 3H-labeled, (3(R))-isomer [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Omacetaxine Mepesuccinate [NCIt concept]
- Omacetaxine mepesuccinate (substance) [SNOMED CT concept]
- omacetaxine mepesuccinate [ATC Code]
Validated automatic mappings to BTNT
- omacetaxine mepesuccinate [ATC Code]

Keyword's position in hierarchy(ies) :

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