Omacetaxine - CISMeF

Preferred Label : Omacetaxine;

NCIt synonyms : Cephalotaxine;

NCIt definition : A protein translation inhibitor and cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus, with potential antineoplastic activity. Although the exact mechanism of action has not been fully elucidated, upon administration, omacetaxine targets and binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This reduces levels of certain oncoproteins and anti-apoptotic proteins.;

UNII : 84MI6OYN4Z;

CAS number : 24316-19-6;

Chemical formula : C18H21NO4;

NCI Metathesaurus CUI : CL1648440;

Codes from synonyms : 368;

Details

Origin ID

C179199;

UMLS CUI

C3528000;

Automatic exact mappings (from CISMeF team)
- cephalotaxine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing omacetaxine mepesuccinate (medicinal product) [SNOMED CT concept]
chemical_or_drug_affects_cell_type_or_tissue
- Ribosome [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Ribosomal Function Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Omacetaxine Mepesuccinate [NCIt concept]
has_target
- Ribosome [NCIt concept]
is_free_acid_or_base_form_of
- Omacetaxine Mepesuccinate [NCIt concept]

Keyword's position in hierarchy(ies) :

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