Cyclic GMP-AMP Synthase

Preferred Label : Cyclic GMP-AMP Synthase;

NCIt synonyms : cGAS; cGAMP synthase; h-cGAS; MB21D1; Mab-21 Domain-Containing Protein 1; 2'3'-cGAMP Synthase; Protein MB21D1; Mab21 Domain-Containing Protein 1; EC 2.7.7.86;

NCIt definition : Cyclic GMP-AMP synthase (522 aa, 59 kDa) is encoded by the human CGAS gene. This protein plays a role both cyclic dinucleotide synthesis and immune response activation.;

Details

Origin ID

C106640;

UMLS CUI

C3811748;

Automatic exact mappings (from CISMeF team)
- Cyclic gmp-amp synthase [OMIM gene]
- anterior cingulate gyrus [UBERON concept]
- cyclic GMP-AMP synthase [HGNC gene]
OMIM relation
- Cyclic gmp-amp synthase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- cGAS protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- CGAS Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Immunity [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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