Preferred Label : aliskiren;
MeSH note : orally active nonpeptidic renin inhibitor;
CISMeF synonym : 2(S),4(S),5(S),7(S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-(4-methoxy-3-(3-methoxypropoxy)phenyl)octanamid
hemifumarate; CGP 060536B; SPP100;
MeSH hyponym : CGP060536B; CGP-060536B;
MeSH Related Number : tekturna; C8A0P8G029;
Related CAS MeSH : C8A0P8G029 (Tekturna);
Is substance : O;
UNII : 502FWN4Q32;
InChIKey : UXOWGYHJODZGMF-QORCZRPOSA-N;
Origin ID : C446481;
UMLS CUI : C1120110;
ATC code(s)
Manual BTNT mappings - CISMeF
MeSH indexing information
MeSH term(s) associated for indexing
Pharmacological action(s)
Record concept(s)
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
http://www.has-sante.fr/portail/jcms/c_2733615/fr/rasilez-aliskiren-rasilez-hct-aliskiren/hydrochlorothiazide-inhibiteur-de-la-renine-en-association-ou-non-a-un-diuretique
http://www.has-sante.fr/portail/jcms/c_2733615/fr/rasilez
2016
false
false
France
French
guidelines for drug use
administration, oral
aliskiren
hydrochlorothiazide
adult
cardiovascular diseases
aliskiren
drug combinations
antihypertensive agents
hydrochlorothiazide
renin
sodium chloride symporter inhibitors
diuretics
insurance, health, reimbursement
treatment outcome
clinical trials as topic
aliskiren and hydrochlorothiazide
evaluation of the transparency committee
hypertension
amides
fumarates
amides
fumarates
---
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37895a-fra.php
2014
Canada
English
French
drug therapy, combination
antihypertensive agents
aliskiren
renin
drug interactions
angiotensin-converting enzyme inhibitors
angiotensin receptor antagonists
hypotension
hyperkalemia
kidney diseases
diabetes mellitus
kidney diseases
stroke
drug therapy, combination
syncope
pharmacovigilance note
patient education handout
amides
fumarates
Contraindications, Procedure
---
http://www.has-sante.fr/portail/jcms/c_810823/rasilez
http://www.has-sante.fr/portail/jcms/c_1528341/fr/rasilez
http://www.has-sante.fr/portail/jcms/c_642565/rasilez
http://www.has-sante.fr/portail/upload/docs/application/pdf/2010-04/rasilez_ct_5216.pdf
http://www.has-sante.fr/portail/jcms/c_1719386/fr/rasilez
2013
false
France
French
hypertension
guidelines for drug use
Substance with renin inhibitor mechanism of action (substance)
aliskiren
antihypertensive agents
administration, oral
renin
aliskiren
insurance, health, reimbursement
treatment outcome
aliskiren
antihypertensive agents
evaluation of the transparency committee
risk assessment
amides
amides
fumarates
fumarates
---
http://www.has-sante.fr/portail/jcms/c_834687/rasilez-hct-aliskiren-et-hydrochlorothiazide-association-dantihypertenseurs
http://www.has-sante.fr/portail/jcms/c_1719374/fr/rasilez-hct
2013
false
France
French
guidelines for drug use
aliskiren
drug combinations
antihypertensive agents
hydrochlorothiazide
renin
sodium chloride symporter inhibitors
diuretics
insurance, health, reimbursement
treatment outcome
clinical trials as topic
aliskiren and hydrochlorothiazide
evaluation of the transparency committee
hypertension
amides
fumarates
---
https://www.ema.europa.eu/medicines/human/EPAR/Riprazo
2012
United Kingdom
French
English
syndication feed
Contraindications, Procedure
antihypertensive agents
antihypertensive agents
antihypertensive agents
antihypertensive agents
antihypertensive agents
pregnancy
tablets
treatment outcome
adult
aged
renin
amides
amides
amides
amides
amides
fumarates
fumarates
fumarates
fumarates
hypertension
fumarates
aliskiren
aliskiren
amides
fumarates
drug evaluation
package leaflet
summary of product characteristics
Contraindications, Drug
---
https://www.ema.europa.eu/medicines/human/EPAR/Sprimeo
2012
United Kingdom
French
English
syndication feed
Contraindications, Procedure
fumarates
antihypertensive agents
fumarates
amides
antihypertensive agents
amides
renin
amides
pregnancy
hypertension
treatment outcome
tablets
adult
aged
antihypertensive agents
amides
fumarates
antihypertensive agents
amides
fumarates
antihypertensive agents
fumarates
aliskiren
aliskiren
amides
fumarates
drug evaluation
package leaflet
summary of product characteristics
Contraindications, Drug
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68717407
2012
France
summary of product characteristics
package leaflet
tablets
amlodipine
aliskiren
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69127637
2012
France
summary of product characteristics
package leaflet
tablets
amlodipine
aliskiren
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65228635
2012
France
summary of product characteristics
package leaflet
amlodipine
aliskiren
tablets
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64880691
2012
France
summary of product characteristics
package leaflet
tablets
amlodipine
aliskiren
---
https://www.revmed.ch/RMS/2012/RMS-351/Y-a-t-il-encore-une-place-pour-la-double-inhibition-du-systeme-renine-angiotensine-en-2012
2012
Switzerland
French
renin-angiotensin system
journal article
Renin-angiotensin system inhibition
angiotensin-converting enzyme inhibitors
angiotensin II type 1 receptor blockers
renin
aliskiren
amides
fumarates
---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/14113a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/14685a-fra.php
2012
Canada
English
French
pharmacovigilance note
patient education handout
cardiovascular risk
Contraindications, Procedure
controlled clinical trials as topic
amides
amides
fumarates
fumarates
administration, oral
drug combinations
aliskiren
antihypertensive agents
aliskiren
aliskiren and hydrochlorothiazide
hydrochlorothiazide
diabetes mellitus, type 2
stroke
kidney diseases
hyperkalemia
hypotension
hypertension
aliskiren
antihypertensive agents
angiotensin-converting enzyme inhibitors
angiotensin receptor antagonists
Contraindications, Drug
---
https://www.ema.europa.eu/medicines/human/EPAR/Rasitrio
2012
false
United Kingdom
English
French
drug evaluation
summary of product characteristics
package leaflet
syndication feed
Product containing precisely aliskiren (as aliskiren fumarate) 150 milligram and amlodipine
(as amlodipine besilate) 5 milligram and hydrochlorothiazide 12.5 milligram/1 each
conventional release oral tablet (clinical drug)
Product containing precisely aliskiren (as aliskiren fumarate) 300 milligram and amlodipine
(as amlodipine besilate) 5 milligram and hydrochlorothiazide 12.5 milligram/1 each
conventional release oral tablet (clinical drug)
Product containing precisely aliskiren (as aliskiren fumarate) 300 milligram and amlodipine
(as amlodipine besilate) 5 milligram and hydrochlorothiazide 25 milligram/1 each conventional
release oral tablet (clinical drug)
Product containing precisely aliskiren (as aliskiren fumarate) 300 milligram and amlodipine
(as amlodipine besilate) 10 milligram and hydrochlorothiazide 12.5 milligram/1 each
conventional release oral tablet (clinical drug)
Product containing precisely aliskiren (as aliskiren fumarate) 300 milligram and amlodipine
(as amlodipine besilate) 10 milligram and hydrochlorothiazide 25 milligram/1 each
conventional release oral tablet (clinical drug)
Product containing aliskiren and amlodipine and hydrochlorothiazide (medicinal product)
amides
amides
fumarates
fumarates
aged
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
hydrochlorothiazide
aliskiren
amlodipine
drug combinations
aliskiren
amlodipine
hydrochlorothiazide
antihypertensive agents
antihypertensive agents
renin
aliskiren, amlodipine and hydrochlorothiazide
calcium channel blockers
calcium channel blockers
administration, oral
adult
hypertension
drug approval
treatment outcome
diuretics
diuretics
sodium chloride symporter inhibitors
sodium chloride symporter inhibitors
vasodilator agents
vasodilator agents
Amlodipine Besylate
---
https://www.ema.europa.eu/medicines/human/EPAR/Rasilamlo
2012
United Kingdom
French
English
summary of product characteristics
package leaflet
drug evaluation
syndication feed
Amlodipine Besylate
aliskiren
amlodipine
drug combinations
administration, oral
aliskiren
amlodipine
hypertension
adult
amides
amides
fumarates
fumarates
antihypertensive agents
antihypertensive agents
renin
calcium channel blockers
calcium channel blockers
vasodilator agents
vasodilator agents
aliskiren and amlodipine
treatment outcome
drug approval
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
---
https://www.ema.europa.eu/medicines/human/EPAR/Rasilez-HCT
2012
United Kingdom
French
English
syndication feed
antihypertensive agents
amides
diuretics
fumarates
hydrochlorothiazide
drug combinations
hydrochlorothiazide
amides
fumarates
tablets
administration, oral
adult
drug approval
aliskiren
aliskiren
breast feeding
diuretics
renin
drug evaluation, preclinical
treatment outcome
drug labeling
aged
drug interactions
pregnancy
aliskiren and hydrochlorothiazide
amides
fumarates
package leaflet
drug evaluation
summary of product characteristics
---
https://www.ema.europa.eu/medicines/human/EPAR/Rasilez
2012
United Kingdom
English
French
syndication feed
adult
hypertension
aged
treatment outcome
antihypertensive agents
antihypertensive agents
amides
amides
fumarates
fumarates
fumarates
pregnancy
breast feeding
drug interactions
drug evaluation, preclinical
drug labeling
drug approval
administration, oral
renin
aliskiren
aliskiren
drug evaluation
summary of product characteristics
package leaflet
---
https://www.ema.europa.eu/medicines/human/EPAR/Sprimeo-HCT
2011
United Kingdom
English
French
drug evaluation
package leaflet
summary of product characteristics
syndication feed
aliskiren
hydrochlorothiazide
drug combinations
administration, oral
drug approval
treatment outcome
aliskiren
amides
amides
fumarates
fumarates
renin
antihypertensive agents
antihypertensive agents
hydrochlorothiazide
diuretics
diuretics
sodium chloride symporter inhibitors
sodium chloride symporter inhibitors
hypertension
aliskiren and hydrochlorothiazide
adult
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
---
https://minerva-ebp.be/fr/article/204
2011
false
false
minerva-ebm.be
Belgium
French
Dutch
critical appraisal or critical reading
amides
fumarates
aliskiren and amlodipine
aliskiren
amlodipine
Amlodipine Besylate
hypertension
aliskiren
amlodipine
antihypertensive agents
calcium channel blockers
drug therapy, combination
renin
drug combinations
double-blind method
---
https://www.ema.europa.eu/medicines/human/EPAR/Enviage
2011
United Kingdom
French
English
syndication feed
Contraindications, Procedure
renin
pregnancy
adult
aged
tablets
treatment outcome
antihypertensive agents
amides
fumarates
antihypertensive agents
amides
fumarates
antihypertensive agents
amides
fumarates
antihypertensive agents
amides
fumarates
antihypertensive agents
amides
fumarates
hypertension
aliskiren
aliskiren
amides
fumarates
drug evaluation
package leaflet
summary of product characteristics
Contraindications, Drug
---
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailOne.php?lang=fr&linkID=SBD00122
2011
false
false
false
Canada
drug information
tablets
fumarates
aliskiren
---
http://www.revmed.ch/RMS/2010/RMS-N-267/Y-a-t-il-une-place-aujourd-hui-pour-les-inhibiteurs-directs-de-la-renine
2010
false
true
false
Switzerland
hypertension
aliskiren
antihypertensive agents
antihypertensive agents
antihypertensive agents
antihypertensive agents
heart failure
diabetic nephropathies
Substance with renin inhibitor mechanism of action (substance)
journal article
renin
amides
fumarates
---
https://www.ema.europa.eu/medicines/human/EPAR/Tekturna
2009
United Kingdom
English
French
syndication feed
Contraindications, Procedure
antihypertensive agents
hypertension
amides
fumarates
renin
fumarates
amides
antihypertensive agents
treatment outcome
adult
fumarates
amides
antihypertensive agents
aged
fumarates
amides
antihypertensive agents
pregnancy
fumarates
amides
antihypertensive agents
tablets
aliskiren
aliskiren
amides
fumarates
drug evaluation
package leaflet
summary of product characteristics
Contraindications, Drug
---
http://www.has-sante.fr/portail/jcms/c_843166/quelle-place-pour-laliskiren-rasilez-dans-le-traitement-antihypertenseur
http://www.has-sante.fr/portail/jcms/c_843161/fiche-bon-usage-rasilez
2009
France
French
hypertension
antihypertensive agents
amides
fumarates
aliskiren
aliskiren
guidelines for drug use
---
https://rmlg.uliege.be/article/1948
2009
Belgium
journal article
renin
aliskiren
hydrochlorothiazide
---
https://rmlg.uliege.be/article/1790
2008
false
Belgium
French
Substance with renin inhibitor mechanism of action (substance)
fumarates
aliskiren
amides
administration, oral
aliskiren
drug therapy, combination
antihypertensive agents
aliskiren
fumarates
amides
antihypertensive agents
renin
amides
fumarates
drug information
journal article
---
https://cadth.ca/sites/default/files/cdr/complete/cdr_complete_Rasilez_july-08_f.pdf
2008
Canada
French
amides
antihypertensive agents
fumarates
renin
hypertension
treatment outcome
canada
insurance, health, reimbursement
aliskiren
aliskiren
amides
fumarates
drug evaluation
---