renin - CISMeF

Preferred Label : renin;

MeSH definition : A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.;

MeSH synonym : angiotensin-forming enzyme; angiotensin forming enzyme; angiotensinogenase;

MeSH hyponym : preprorenin; prorenin; Inactive Renin; Renin, Inactive; Big Renin; Renin, Big; Cryorenin; Pre-Prorenin; Pre Prorenin;

CISMeF hyponym : EC 3.4.23.-;

MeSH Related Number : prorenin; preprorenin; 80965-96-4 (CRN);

Registry Number MeSH : EC 3.4.23.15;

Related CAS MeSH : EC 3.4.23.- (Prorenin); EC 3.4.23.- (Preprorenin);

MeSH annotation : do not confuse with RENNIN see CHYMOSIN;

Wikipedia link : https://en.wikipedia.org/wiki/Renin;

Is substance : O;

UNII : EC 3.4.23.15;

Details

Origin ID

D012083;

UMLS CUI

C0035094;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Substance with renin inhibitor mechanism of action (substance) [SNOMED CT concept]
Indexing information
- 4-N-(morpholinoacetyl-(1-naphthyl)-alanyl-N-methyl-(4-thiazolyl)-alanyl)amino-3-hydroxy-5-cyclohexyl-1-(4-pyridyl)-1-pentanone [MeSH Supplementary Concept]
- 4-cyclohexyl-2-hydroxy-3-((2-((2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl)amino)pentanoyl)amino)butyric acid isopropyl ester [MeSH Supplementary Concept]
- 5,8-diaza-10,11-dihydroxy-9-cyclohexylmethyl-13-methyl-1-(4-methylpiperazin-1-yl)-3-phenylmethyl-6-(thiazol-4-ylmethyl)tetradecane-1,4,7-trione [MeSH Supplementary Concept]
- 5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid [MeSH Supplementary Concept]
- 5-amino-4-hydroxy-7-(4-methoxy-3-(3-methoxypropyl)benzyl)-2,8-dimethylnonanoic acid butylamide [MeSH Supplementary Concept]
- A 62095 [MeSH Supplementary Concept]
- A 62198 [MeSH Supplementary Concept]
- A 65317 [MeSH Supplementary Concept]
- A 74273 [MeSH Supplementary Concept]
- ATP6AP2 protein, human [MeSH Supplementary Concept]
- BILA 2157 BS [MeSH Supplementary Concept]
- BW 175 [MeSH Supplementary Concept]
- BW 633C [MeSH Supplementary Concept]
- CGP 29287 [MeSH Supplementary Concept]
- CGP 38560 [MeSH Supplementary Concept]
- CGP 44099 [MeSH Supplementary Concept]
- CGP 60536 [MeSH Supplementary Concept]
- CI 992 [MeSH Supplementary Concept]
- CP 71362 [MeSH Supplementary Concept]
- CP 81282 [MeSH Supplementary Concept]
- CP 85339 [MeSH Supplementary Concept]
- EMD 51921 [MeSH Supplementary Concept]
- EMD 52297 [MeSH Supplementary Concept]
- EMD 55068 [MeSH Supplementary Concept]
- EMD 55450 [MeSH Supplementary Concept]
- EMD 56133 [MeSH Supplementary Concept]
- EMD 58265 [MeSH Supplementary Concept]
- ES 1005 [MeSH Supplementary Concept]
- ES 305 [MeSH Supplementary Concept]
- ES 6864 [MeSH Supplementary Concept]
- ES 8891 [MeSH Supplementary Concept]
- FK 906 [MeSH Supplementary Concept]
- GR 70982 [MeSH Supplementary Concept]
- H 142 [MeSH Supplementary Concept]
- H 189 [MeSH Supplementary Concept]
- H 218-54 [MeSH Supplementary Concept]
- H 261 [MeSH Supplementary Concept]
- H 77 [MeSH Supplementary Concept]
- KRI 1177 [MeSH Supplementary Concept]
- KRI 1230 [MeSH Supplementary Concept]
- KRI 1314 [MeSH Supplementary Concept]
- L 363714 [MeSH Supplementary Concept]
- N-(1-cyclohexylmethyl-2,4-dihydroxy-5-methylhexyl)-N(alpha)-methyl-N(alpha)-(N-(4-hydroxypiperidino)carbonyl-phenylalanyl)histidinamide [MeSH Supplementary Concept]
- N-(2-((1-(cyclohexylmethyl)-2-(3-ethyl-2-oxo-5-oxazolidinyl)-2-hydroxyethyl)amino)-2-oxo-1-(2-thienylmethyl)ethyl)-gamma-oxo-alpha-(phenylmethyl)-4-morpholinebutanamide [MeSH Supplementary Concept]
- N-acetylphenylalanyl-N-(4-((butylamino)carbonyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl)norleucinamide [MeSH Supplementary Concept]
- PD 125754 [MeSH Supplementary Concept]
- PD 125967 [MeSH Supplementary Concept]
- PD 132002 [MeSH Supplementary Concept]
- PD 134672 [MeSH Supplementary Concept]
- PD 134922 [MeSH Supplementary Concept]
- PD 135390 [MeSH Supplementary Concept]
- RENBP protein, human [MeSH Supplementary Concept]
- RI 78 [MeSH Supplementary Concept]
- S 2864 [MeSH Supplementary Concept]
- S 862033 [MeSH Supplementary Concept]
- S 863390 [MeSH Supplementary Concept]
- SC 46944 [MeSH Supplementary Concept]
- SC 51106 [MeSH Supplementary Concept]
- SDZ 213-776 [MeSH Supplementary Concept]
- SQ 30774 [MeSH Supplementary Concept]
- SQ 31844 [MeSH Supplementary Concept]
- SQ 32970 [MeSH Supplementary Concept]
- SR 42128 [MeSH Supplementary Concept]
- SR 43845 [MeSH Supplementary Concept]
- U 70714E [MeSH Supplementary Concept]
- U 77436 [MeSH Supplementary Concept]
- U 80215 [MeSH Supplementary Concept]
- YM 21095 [MeSH Supplementary Concept]
- YM 26365 [MeSH Supplementary Concept]
- aliskiren [MeSH Supplementary Concept]
- ciprokiren [MeSH Supplementary Concept]
- cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide [MeSH Supplementary Concept]
- cyclothiazomycin [MeSH Supplementary Concept]
- ditekiren [MeSH Supplementary Concept]
- enalkiren [MeSH Supplementary Concept]
- ethyl 2-benzyl-3-((1-methyl-1-((morpholin-4-yl)carbonyl)ethyl)sulfonyl)propionate [MeSH Supplementary Concept]
- ethyl 2-benzyl-3-(tert-butylsulfonyl)propionate [MeSH Supplementary Concept]
- methyl (2-((3-chlorophenyl)(1-((2-(methylamino)-3-(tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate [MeSH Supplementary Concept]
- pepstatyl, Asp-Arg- [MeSH Supplementary Concept]
- pepstatyl, asp- [MeSH Supplementary Concept]
- pepstatyl, glu- [MeSH Supplementary Concept]
- pepstatyl-arginine methyl ester [MeSH Supplementary Concept]
- remikiren [MeSH Supplementary Concept]
- renbp protein, mouse [MeSH Supplementary Concept]
- renbp protein, rat [MeSH Supplementary Concept]
- renin inhibitory peptide [MeSH Supplementary Concept]
- renin inhibitory peptide, 4-amino-5-cyclohexyl-3-hydroxypentanoic acid [MeSH Supplementary Concept]
- renin inhibitory peptide, R-PEP-27 [MeSH Supplementary Concept]
- renin inhibitory peptide, statine [MeSH Supplementary Concept]
- tert-butyloxycarbonyl-4-amino-3-hydroxy-5-cyclohexylpentanoic acid [MeSH Supplementary Concept]
- zankiren hydrochloride [MeSH Supplementary Concept]
Record concept(s)
- preprorenin [MeSH concept]
- prorenin [MeSH concept]
- renin [MeSH concept]
Related MeSH Supplementary Concept(s)
- EMD 52859 [MeSH Supplementary Concept]
- PRO20 peptide [MeSH Supplementary Concept]
- Ren2 protein, mouse [MeSH Supplementary Concept]
- Ren2 protein, rat [MeSH Supplementary Concept]
- gamma-renin [MeSH Supplementary Concept]
- glycosylated renin [MeSH Supplementary Concept]
- hyperuricemic nephropathy, familial juvenile 2 [MeSH Supplementary Concept]
- mRen2 protein, rat [MeSH Supplementary Concept]
- peptide 8A [MeSH Supplementary Concept]
See also
- juxtaglomerular apparatus [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Renin [NCIt concept]
- Renin [LOINC part]
- Renin [LOINC component]
- Renin (substance) [SNOMED CT concept]
- renin [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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