" /> Aliskiren - CISMeF





Preferred Label : Aliskiren;

NCIt synonyms : (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide;

NCIt definition : An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in the renin-angiotensin-aldosterone system (RAAS) that is responsible for converting angiotensinogen to angiotensin I (AT I). By inhibiting the activity of renin, the conversion to AT I is prevented, which in turn prevents the conversion of AT I to AT II. This prevents arterial vasoconstriction by AT II and inhibits the production of aldosterone by AT II. As aldosterone causes re-uptake of sodium and water and eventually an increase in extracellular volume, aliskiren is able to prevent the effects that contribute to an increase in blood pressure.;

UNII : 502FWN4Q32;

InChIKey : UXOWGYHJODZGMF-QORCZRPOSA-N;

CAS number : 173334-57-1;

Drug name : Tekturna;

Molecule name : SPP100; CGP 60536;

Chemical formula : C30H53N3O6;

ChEBI ID : CHEBI:601027;

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29/05/2025


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