Preferred Label : sapropterin;
MeSH note : RN given refers to parent cpd; co-factor required for catalytic activity of nitric
oxide synthases;
CISMeF synonym : 5,6,7,8-tetrahydrobiopterin; 5,6,7,8-erythro-tetrahydrobiopterin; 5,6,7,8-tetrahydro-L-erythrobiopterin; 5,6,7,8-tetrahydrodictyopterin; 6R-L-erythro-5,6,7,8-tetrahydrobiopterin; D-threo-tetrahydrobiopterin; kuvan; sapropterin dihydrochloride; BPH4; phenylalanine hydroxylase cofactor; tetrahydro-6-biopterin;
MeSH synonym : tetrahydrobiopterin; 6R-BH4;
Related MeSH term : THBP; 1-butanone, 1-(2,4,5-trihydroxyphenyl); trihydroxybutyrophenone; 2',4',5'-trihydroxybutyrophenone;
MeSH Related Number : 5,6,7,8-tetrahydrobiopterin, (S-(R*,S*))-isomer; 27070-47-9 (cpd with unspecified locants (S-(R*,S*))-isomer); 17528-72-2; KN729W3LR0; RG277LF5B3;
Registry Number MeSH : 17528-72-2;
Related CAS MeSH : 27070-47-9 (5,6,7,8-tetrahydrobiopterin, (S-(R*,S*))-isomer);
related registry number list (CISMeF) : 27070-47-9 (cpd with unspecified locants (S-(R*,S*))-isomer);
Is substance : O;
UNII : EGX657432I;
InChIKey : FNKQXYHWGSIFBK-RPDRRWSUSA-N;
Origin ID : C003402;
UMLS CUI : C0048897;
ATC code(s)
Currated CISMeF NLP mapping
MeSH indexing information
MeSH term(s) associated for indexing
Record concept(s)
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
https://www.has-sante.fr/jcms/p_3419182/fr/sapropterine-dipharma-sapropterine-hyperphenylalaninemie-hpa
2023
false
false
false
France
hyperphenylalaninemia, Non-Phenylketonuric
treatment outcome
insurance, health, reimbursement
administration, oral
Product containing only sapropterin in oral dose form (medicinal product form)
powders
sapropterin
adult
child
adolescent
evaluation of the transparency committee
sapropterin dihydrochloride
hyperphenylalaninaemia
phenylketonurias
sapropterin
---
https://www.ema.europa.eu/en/medicines/human/EPAR/sapropterin-dipharma
2022
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
sapropterin
sapropterin
sapropterin
drugs, generic
---
http://www.has-sante.fr/portail/jcms/c_2586909/fr/kuvan
2015
false
false
false
France
French
evaluation of the transparency committee
administration, oral
infant, newborn
child
infant
treatment outcome
sapropterin
sapropterin
phenylketonurias
hyperphenylalaninaemia
orphan drug production
sapropterin
Biopterins
Biopterins
Biopterins
---
http://www.cochrane.org/fr/CD008005
2015
false
France
United Kingdom
French
french abstract
meta-analysis
phenylketonurias
treatment outcome
Biopterins
sapropterin
---
https://www.jle.com/fr/revues/bio_rech/jpc/e-docs/00/04/1E/AD/resume.md?type=text.html
France
journal article
case management
phenylketonurias
sapropterin
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64768991
2012
France
summary of product characteristics
package leaflet
tablets
sapropterin
---
https://www.ema.europa.eu/medicines/human/EPAR/Kuvan
2012
United Kingdom
French
English
syndication feed
tablets
administration, oral
drug approval
Biopterins
orphan drug production
treatment outcome
adult
adolescent
child
phenylketonurias
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
Biopterins
Biopterins
Biopterins
sapropterin
sapropterin
sapropterin
sapropterin
package leaflet
drug evaluation
summary of product characteristics
---
Summary Basis of Decision (SBD) for KUVAN - Sapropterin dihydrochloride
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailOne.php?lang=fr&linkID=SBD00083
2010
false
Canada
French
enzyme activators
phenylalanine hydroxylase
sapropterin
Biopterins
sapropterin
phenylketonurias
drug information
---
http://www.has-sante.fr/portail/jcms/c_757307/kuvan
http://www.has-sante.fr/portail/upload/docs/application/pdf/2009-03/kuvan_-_ct-6206.pdf
http://www.has-sante.fr/portail/upload/docs/application/pdf/2010-11/kuvan_ct_6206.pdf
2009
France
French
English
sapropterin
orphan drug production
sapropterin
Biopterins
administration, oral
phenylketonurias
adult
child
infant
treatment outcome
sapropterin
evaluation of the transparency committee
guidelines for drug use
---