CLOCK proteins

Preferred Label : CLOCK proteins;

MeSH definition : Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.;

MeSH synonym : CLOCK protein; circadian locomotor output cycles kaput proteins;

Registry Number MeSH : EC 2.3.1.48;

Is substance : O;

UNII : EC 2.3.1.48;

Details

Origin ID

D056926;

UMLS CUI

C2717934;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CREB-Binding Protein [NCIt concept]
- General Transcription Factor 3C Polypeptide 4 [NCIt concept]
- Histone Acetylase [NCIt concept]
- Histone Acetyltransferase KAT7 [NCIt concept]
- Histone Acetyltransferase KAT8 [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Nuclear Receptor Coactivator 1 [NCIt concept]
- Nuclear Receptor Coactivator 3 [NCIt concept]
Record concept(s)
- CLOCK proteins [MeSH concept]
Related MeSH Supplementary Concept(s)
- CLOCK protein, human [MeSH Supplementary Concept]
- clk protein, drosophila [MeSH Supplementary Concept]
- clock protein, mouse [MeSH Supplementary Concept]
- clock protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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