MeSH definition : Widely distributed enzymes that carry out oxidation-reduction reactions in which one
atom of the oxygen molecule is incorporated into the organic substrate; the other
oxygen atom is reduced and combined with hydrogen ions to form water. They are also
known as monooxygenases or hydroxylases. These reactions require two substrates as
reductants for each of the two oxygen atoms. There are different classes of monooxygenases
depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the
mixed-function oxidation.;
MeSH synonym : monooxygenases; hydroxylases; mixed function oxidases; oxidases, mixed function; oxygenases, mixed function; Hydroxylase; Mixed Function Oxidase; Function Oxidase, Mixed; Oxidase, Mixed Function; Monooxygenase; Mixed Function Oxygenase; Function Oxygenase, Mixed; Oxygenase, Mixed Function;
Registry Number MeSH : EC 1.-;
MeSH annotation : do not confuse with HYDRO-LYASES;
Widely distributed enzymes that carry out oxidation-reduction reactions in which one
atom of the oxygen molecule is incorporated into the organic substrate; the other
oxygen atom is reduced and combined with hydrogen ions to form water. They are also
known as monooxygenases or hydroxylases. These reactions require two substrates as
reductants for each of the two oxygen atoms. There are different classes of monooxygenases
depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the
mixed-function oxidation.
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=99763 2011 France scientific and technical information mixed function oxygenases Cytochrome P-450 CYP11B2 hypoaldosteronism 18-Hydroxylase deficiency corticosterone 18-Hydroxylase deficiency corticosterone 18-monooxygenase deficiency cardiomyopathy, hypertrophic corticosterone methyl oxidase I
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--- http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=209902 2011 France scientific and technical information hypercholesterolemia cholesterol mixed function oxygenases
--- http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=101150 2011 France scientific and technical information Dopa-responsive dystonia dystonia dihydroxyphenylalanine mixed function oxygenases segawa syndrome, autosomal recessive