Cytochrome P-450 CYP11B2

Preferred Label : Cytochrome P-450 CYP11B2;

Obsolete resource : false;

MeSH definition : A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.;

MeSH synonym : aldosynthase; steroid 18-hydroxylase; cytochrome p450aldo; cyp 11b2; cytochrome p-450c11as; steroid 18 hydroxylase; aldosterone synthase cytochrome p-450; cyp11b2; cytochrome p450 11b2; cytochrome p 450 cyp11b2; cytochrome p 450c11as; p450c11as; Aldosterone Synthase;

CISMeF synonym : cyctochrome p-450 c11as;

Related MeSH term : 18-monooxygenase, Corticosterone; Corticosterone 18 monooxygenase; Corticosterone 18-hydroxylase; 18-hydroxylase, Corticosterone; Corticosterone 18 hydroxylase;

MeSH Related Number : 37256-75-0 (CRN); EC 1.14.15.4;

Registry Number MeSH : EC 1.14.15.4;

MeSH annotation : /antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS;

Wikipedia link : https://en.wikipedia.org/wiki/Aldosterone synthase;

Is substance : O;

UNII : EC 1.14.15.4;

Details

Origin ID

D019405;

UMLS CUI

C0075233;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CYP11B2 Gene [NCIt concept]
- Corticosterone 18-monooxygenase (substance) [SNOMED CT concept]
- Cytochrome p450, subfamily xib, polypeptide 2 [OMIM gene]
- corticosterone 18-monooxygenase [SNOMED Notion]
- cytochrome P450 family 11 subfamily B member 2 [ORDO Gene]
- steroid 11-beta-monooxygenase activity [GO term]
Indexing information
- 4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile [MeSH Supplementary Concept]
- 5-((5-chloro-2,3-dihydro-1H-inden-1-ylidene)methyl)-1H-imidazole [MeSH Supplementary Concept]
- Osilodrostat [MeSH Supplementary Concept]
Record concept(s)
- Cytochrome P-450 CYP11B2 [MeSH concept]
- corticosterone 18-monooxygenase [MeSH concept]
Related MeSH Supplementary Concept(s)
- 18-Hydroxylase deficiency [MeSH Supplementary Concept]
- Cyp11b3 protein, rat [MeSH Supplementary Concept]
- corticosterone methyl oxidase I [MeSH Supplementary Concept]
- corticosterone methyl oxidase II [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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