Preferred Label : dna damage;
MeSH definition : Injuries to DNA that introduce deviations from its normal, intact structure and which
may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These
deviations may be caused by physical or chemical agents and occur by natural or unnatural,
introduced circumstances. They include the introduction of illegitimate bases during
replication or by deamination or other modification of bases; the loss of a base from
the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks;
and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often
be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.;
MeSH synonym : dna injuries; injury, dna; dna injury; DNA Lesions; DNA Lesion;
CISMeF synonym : damage, dna; injuries, dna; damages, dna; dna damages;
MeSH hyponym : genotoxic stress; Genotoxic Stresses; Stresses, Genotoxic; Stress, Genotoxic;
MeSH annotation : do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not
confuse with DNA FRAGMENTATION: see note there;
Origin ID : D004249;
UMLS CUI : C0012860;
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Indexing information
- (5,6-(4,5-dichlorobenzo)-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane)oxochromate(V) [MeSH Supplementary Concept]
- vaby D [MeSH Supplementary Concept]
Metaterm(s)
Record concept(s)
See also
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
Injuries to DNA that introduce deviations from its normal, intact structure and which
may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These
deviations may be caused by physical or chemical agents and occur by natural or unnatural,
introduced circumstances. They include the introduction of illegitimate bases during
replication or by deamination or other modification of bases; the loss of a base from
the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks;
and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often
be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
https://www.anses.fr/fr/content/fig%C3%A9-fr%C3%A9quences-interm%C3%A9diaires-et-stress-g%C3%A9notoxique
2022
France
scientific and technical information
genotoxic stress
dna damage
Stress
absence of stress
stress, nos
Stress
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http://archives.uness.fr/sites/unf3s/media/paces/Grenoble_1112/lunardi_joel/lunardi_joel_p04/lunardi_joel_p04.pdf
http://archives.uness.fr/sites/unf3s/media/paces/Grenoble_1112/lunardi_joel/lunardi_joel_p04/index.htm
2012
false
true
false
true
PACES / bac 1
France
French
educational course
dna damage
recombination, genetic
audiovisual aids
molecular biology
genetic variation
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