dna damage - CISMeF

Preferred Label : dna damage;

MeSH definition : Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.;

MeSH synonym : dna injuries; injury, dna; dna injury; DNA Lesions; DNA Lesion;

CISMeF synonym : damage, dna; injuries, dna; damages, dna; dna damages;

MeSH hyponym : genotoxic stress; Genotoxic Stresses; Stresses, Genotoxic; Stress, Genotoxic;

MeSH annotation : do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there;

Details

Origin ID

D004249;

UMLS CUI

C0012860;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- ethics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Gene Mutation [NCIt concept]
- Genotoxic Stress [NCIt concept]
Currated CISMeF NLP mapping
- DNA Damage [NCIt concept]
- DNA damage [Disease (Nov.)]
- Deoxyribonucleic acid damage (finding) [SNOMED CT concept]
- dna damage [SNOMED Notion]
Indexing information
- (5,6-(4,5-dichlorobenzo)-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane)oxochromate(V) [MeSH Supplementary Concept]
- 1,N(2)-propanodeoxyguanosine [MeSH Supplementary Concept]
- 2-phenylbenzimidazole [MeSH Supplementary Concept]
- DDB1 protein, human [MeSH Supplementary Concept]
- Ddb1 protein, mouse [MeSH Supplementary Concept]
- Ddb1 protein, rat [MeSH Supplementary Concept]
- Ddb1 protein, xenopus [MeSH Supplementary Concept]
- Ddb2 protein, mouse [MeSH Supplementary Concept]
- Dds20 protein, S pombe [MeSH Supplementary Concept]
- GADD45 protein [MeSH Supplementary Concept]
- MUS81 protein, Drosophila [MeSH Supplementary Concept]
- MUS81 protein, S cerevisiae [MeSH Supplementary Concept]
- MUS81 protein, human [MeSH Supplementary Concept]
- Mms22 protein, S cerevisiae [MeSH Supplementary Concept]
- Mus81 protein, mouse [MeSH Supplementary Concept]
- N-hydroxyacridinethione [MeSH Supplementary Concept]
- N-hydroxypyridine-4-thione [MeSH Supplementary Concept]
- P(OH)(2)TBCS(n) [MeSH Supplementary Concept]
- PPP1R15A protein, human [MeSH Supplementary Concept]
- RAD5a protein, arabidopsis [MeSH Supplementary Concept]
- Rdp1 protein, S pombe [MeSH Supplementary Concept]
- Tial1 protein, mouse [MeSH Supplementary Concept]
- amalakirasayana [MeSH Supplementary Concept]
- anti-silencing factor 1, leishmania major [MeSH Supplementary Concept]
- fragmentin [MeSH Supplementary Concept]
- hus1 protein, S pombe [MeSH Supplementary Concept]
- tetraruthenated porphyrin [MeSH Supplementary Concept]
- vaby D [MeSH Supplementary Concept]
Metaterm(s)
- oncology [CISMeF Metaterm]
Record concept(s)
- DNA damage [MeSH concept]
- genotoxic stress [MeSH concept]
See also
- comet assay [MeSH Descriptor]
- dna repair [MeSH Descriptor]
- dna repair enzymes [MeSH Descriptor]
- mutation [MeSH Descriptor]
- pyrimidine dimers [MeSH Descriptor]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- DNA Damage [NCIt concept]
- DNA damage [Disease (Nov.)]
- Deoxyribonucleic acid damage (finding) [SNOMED CT concept]
- dna damage [SNOMED Notion]
Validated automatic mappings to BTNT
- Genotoxic Stress [NCIt concept]

Keyword's position in hierarchy(ies) :

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