Genotoxic Stress

Preferred Label : Genotoxic Stress;

NCIt definition : Exposure to DNA-damaging agents and subsequent energy expenditures by a cell to repair DNA damage. Genotoxic stress elicits biochemical responses that either enhance cell survival or lead to cell death. These biochemical responses include DNA-damage-inducible repair and increasing expression of a variety of proteins by both transcriptional and post-transcriptional mechanisms. Genotoxic stresses frequently activate signal transduction pathways that originate in the cell membrane or cytoplasm, triggering similar phosphorylation cascades to those induced by the activation of cell-surface receptors.;

Details

Origin ID

C19419;

UMLS CUI

C1257899;

Automatic exact mappings (from CISMeF team)
- dna damage [MeSH Descriptor]
Currated CISMeF NLP mapping
- genotoxic stress [MeSH concept]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- genotoxic stress [MeSH concept]
Validated automatic mappings to NTBT
- dna damage [MeSH Descriptor]
biological_process_has_associated_location
- Chromosome Structure [NCIt concept]
biological_process_has_result_biological_process
- Cellular Stress Response [NCIt concept]
- DNA Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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