amyotrophic lateral sclerosis

Preferred Label : amyotrophic lateral sclerosis;

MeSH definition : A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94);

MeSH synonym : disease, Lou-Gehrigs; Lou-Gehrigs disease; gehrig's disease; gehrigs disease; motor neuron disease, amyotrophic lateral sclerosis; lou gehrig disease; sclerosis, amyotrophic lateral; lou gehrig's disease; gehrig disease; charcot disease; ALS - Amyotrophic Lateral Sclerosis; ALS Amyotrophic Lateral Sclerosis;

CISMeF synonym : lou gehrigs disease; lateral scleroses, amyotrophic; als (amyotrophic lateral sclerosis);

CISMeF acronym : ALS;

MeSH hyponym : amyotrophic lateral Sclerosis-Parkinsonism/dementia complex 1; amyotrophic lateral sclerosis, Parkinsonism/Dementia complex of guam; amyotrophic lateral sclerosis, guam form; Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam; Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam; Guam Form of Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1; Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1; Guam Disease; Disease, Guam;

Related MeSH term : amyotrophic lateral sclerosis with dementia; Dementia With Amyotrophic Lateral Sclerosis;

Wikipedia link : https://en.wikipedia.org/wiki/Amyotrophic lateral sclerosis;

Details

Origin ID

D000690;

UMLS CUI

C0002736;

Allowable qualifiers
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemically induced [MeSH Qualifier]
- classification [MeSH Qualifier]
- complications [MeSH Qualifier]
- congenital [MeSH Qualifier]
- diagnosis [MeSH Qualifier]
- diagnostic imaging [MeSH Qualifier]
- diet therapy [MeSH Qualifier]
- drug therapy [MeSH Qualifier]
- economics [MeSH Qualifier]
- embryology [MeSH Qualifier]
- enzymology [MeSH Qualifier]
- epidemiology [MeSH Qualifier]
- ethnology [MeSH Qualifier]
- etiology [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- microbiology [MeSH Qualifier]
- mortality [MeSH Qualifier]
- nursing [MeSH Qualifier]
- parasitology [MeSH Qualifier]
- pathology [MeSH Qualifier]
- physiopathology [MeSH Qualifier]
- prevention and control [MeSH Qualifier]
- psychology [MeSH Qualifier]
- radiotherapy [MeSH Qualifier]
- rehabilitation [MeSH Qualifier]
- surgery [MeSH Qualifier]
- therapy [MeSH Qualifier]
- urine [MeSH Qualifier]
- veterinary [MeSH Qualifier]
- virology [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Aldolase [LOINC component]
- Aldolase [MedDRA Preferred Term]
- Aluminum [LOINC component]
- Aluminum [MedDRA LLT]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Anterior horn cell disease (disorder) [SNOMED CT concept]
- Antilymphocyte Serum [NCIt concept]
- Attoliter [NCIt concept]
- Charcoal [LOINC component]
- Charcot's syndrome [MedDRA LLT]
- Cross-sectional Thickness at End Ventricular Diastole [NCIt concept]
- Cross-sectional Thickness at End Ventricular Systole [NCIt concept]
- Guam-Parkinson dementia [PASCAL descriptor]
- IGFALS wt Allele [NCIt concept]
- Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit [NCIt concept]
- Insulin-like growth factor-binding protein, acid-labile subunit [OMIM gene]
- Largest Cross-sectional Thickness [NCIt concept]
- Motor neuron disease [ICD-10 Sub-category]
- Motor neuron disease [ICD-10 Sub-category (who)]
- Motor neuron disease [ORDO Disease]
- Parkinson-dementia complex of Guam (disorder) [SNOMED CT concept]
- Physically Feel in Bad Condition [NCIt concept]
- SLA Gene [NCIt concept]
- SOD1 wt Allele [NCIt concept]
- Src-Like-Adapter [NCIt concept]
- Src-like adaptor [OMIM gene]
- aluminum, nos [SNOMED Notion]
- fructose-bisphosphate aldolase [SNOMED Notion]
- insulin like growth factor binding protein acid labile subunit [ORDO Gene]
- parkinson-dementia complex of guam [SNOMED Notion]
- superoxide dismutase 1 [ORDO Gene]
- surgical soap [Artificial nutrition thesaurus concept]
CISMeF manual mappings
- Parkinson-dementia complex of Guam [ORDO Disease]
Currated CISMeF NLP mapping
- ALS [MedDRA LLT]
- Amyotrophic Lateral Sclerosis [NCIt concept]
- Amyotrophic lateral sclerosis [PASCAL descriptor]
- Amyotrophic lateral sclerosis [MedDRA Preferred Term]
- Amyotrophic lateral sclerosis [ICD-11 Subcategory]
- Amyotrophic lateral sclerosis [OMIM phenotypic series]
- Amyotrophic lateral sclerosis [ICD-9 code]
- Amyotrophic lateral sclerosis [HPO term]
- Amyotrophic lateral sclerosis [ORDO Disease]
- Amyotrophic lateral sclerosis (disorder) [SNOMED CT concept]
- amyotrophic lateral sclerosis [DO Concept]
- amyotrophic lateral sclerosis [Disease (Nov.)]
- amyotrophic lateral sclerosis [SNOMED Notion]
- amyotrophic lateral sclerosis [MedlinePlus Topic]
- amyotrophic lateral sclerosis [Artificial nutrition thesaurus concept]
- amyotrophic lateral sclerosis [Radlex concept]
- amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 [DO Concept]
DO Cross reference
- amyotrophic lateral sclerosis [DO Concept]
- amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 [DO Concept]
False automatic mappings
- Acid Labile Subunit Measurement [NCIt concept]
- Alabama [NCIt concept]
- Albania [NCIt concept]
HPO term
- Amyotrophic lateral sclerosis [HPO term]
Indexing information
- ALS2 protein, human [MeSH Supplementary Concept]
- Edaravone [MeSH Descriptor]
- SOD1 G93A protein [MeSH Supplementary Concept]
- STRADB protein, human [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- Acquired motor neuron disease [ORDO Disease]
- Genetic motor neuron disease [ORDO Disease]
Manual NTBT mappings (CISMeF)
- Autosomal dominant distal hereditary motor neuropathy [ORDO Disease]
- Neurodegenerative disease with dementia [ORDO Disease]
- Rare neurodegenerative disease [ORDO Disease]
MedlinePlus topic(s)
- amyotrophic lateral sclerosis [MedlinePlus Topic]
ORDO relation(s)
- Amyotrophic lateral sclerosis [ORDO Disease]
Record concept(s)
- amyotrophic lateral sclerosis [MeSH concept]
- amyotrophic lateral sclerosis with dementia [MeSH concept]
- amyotrophic lateral sclerosis, guam form [MeSH concept]
Related MeSH Supplementary Concept(s)
- amyotrophic lateral sclerosis 1 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 10 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 11 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 2, juvenile [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 3 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 4, juvenile [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 5 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 6, autosomal recessive [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 7 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 8 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis 9 [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis with polyglucosan bodies [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis, autosomal recessive [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis, juvenile, with dementia [MeSH Supplementary Concept]
- amyotrophic lateral sclerosis, type 6 [MeSH Supplementary Concept]
- frontotemporal dementia with motor neuron disease [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Amyotrophic lateral sclerosis, parkinsonism, dementia complex (disorder) [SNOMED CT concept]
- Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 [OMIM Phenotype]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- ALS [MedDRA LLT]
- Amyotrophic Lateral Sclerosis [NCIt concept]
- Amyotrophic lateral sclerosis [ORDO Disease]
- Amyotrophic lateral sclerosis [MedDRA Preferred Term]
- Amyotrophic lateral sclerosis [HPO term]
- Amyotrophic lateral sclerosis [ICD-9 code]
- Amyotrophic lateral sclerosis (disorder) [SNOMED CT concept]
- amyotrophic lateral sclerosis [Radlex concept]
- amyotrophic lateral sclerosis [SNOMED Notion]
- amyotrophic lateral sclerosis [DO Concept]
- amyotrophic lateral sclerosis [Disease (Nov.)]
- amyotrophic lateral sclerosis [MedlinePlus Topic]
Validated automatic mappings to BTNT
- Amyotrophic lateral sclerosis with dementia (disorder) [SNOMED CT concept]
- amyotrophic lateral sclerosis parkinsonism dementia [Disease (Nov.)]

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