Preferred Label : amyotrophic lateral sclerosis;
RADLEX synonyms : ALS;
Definition : A degenerative disorder affecting upper motor neurons in the brain and lower motor
neurons in the brain stem and spinal cord. Disease onset is usually after the age
of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations
include progressive weakness, atrophy, fasciculation, hyperreflexia, dysarthria, dysphagia,
and eventual paralysis of respiratory function. Pathologic features include the replacement
of motor neurons with fibrous astrocytes and atrophy of anterior spinal nerve roots
and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
[MeSH];
UMLS CUI (RADLEX) : C0002736;
Origin ID : RID5128;
UMLS CUI : C0002736;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
A degenerative disorder affecting upper motor neurons in the brain and lower motor
neurons in the brain stem and spinal cord. Disease onset is usually after the age
of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations
include progressive weakness, atrophy, fasciculation, hyperreflexia, dysarthria, dysphagia,
and eventual paralysis of respiratory function. Pathologic features include the replacement
of motor neurons with fibrous astrocytes and atrophy of anterior spinal nerve roots
and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
[MeSH]
