amiloride - CISMeF

Preferred Label : amiloride;

MeSH definition : A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705);

CISMeF synonym : trommsdorff brand of amiloride hydrochloride; berolina brand of amiloride hydrochloride; amrad brand of amiloride hydrochloride; alphapharm brand of amiloride hydrochloride; merck sharp & dohme brand of amiloride hydrochloride; cahill may roberts brand of amiloride hydrochloride; merck brand of amiloride hydrochloride; douglas brand of amiloride hydrochloride;

MeSH hyponym : midamor; amiloberag; kaluril; amiduret trom; midoride; Amiloride Hydrochloride; Amiloride Hydrochloride, Anhydrous; amidal; Trom, Amiduret; Anhydrous Amiloride Hydrochloride; Hydrochloride, Anhydrous Amiloride; Modamide; Hydrochloride, Amiloride;

MeSH CAS label : pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-;

MeSH Related Number : amiloride hydrochloride, anhydrous; amiloride hydrochloride; 17440-83-4 (Amiloride hydrochloride); 2609-46-3 (Amiloride); 2016-88-8; FZJ37245UC;

Registry Number MeSH : 2609-46-3;

Related CAS MeSH : 2016-88-8 (Amiloride hydrochloride, anhydrous); FZJ37245UC (Amiloride hydrochloride);

Wikipedia link : https://en.wikipedia.org/wiki/Amiloride;

Codes EINECS : 220-024-7;

Is substance : O;

UNII : 7DZO8EB0Z3;

InChIKey : XSDQTOBWRPYKKA-UHFFFAOYSA-N;

Details

Origin ID

D000584;

UMLS CUI

C0002502;

ATC code(s)
- atenolol, thiazides and other diuretics [ATC Code]
ATC code(s)
- amiloride [ATC Code]
- atenolol, thiazides and other diuretics [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- ANHYDROUS AMILORIDE HYDROCHLORIDE [SMS substance]
- Amidation [NCIt concept]
- Amide (substance) [SNOMED CT concept]
- Amiloride Hydrochloride [NCIt concept]
- Amiloride hydrochloride [Substance BNPC]
- Amiloride hydrochloride (substance) [SNOMED CT concept]
- amides [ATC Code]
- amides [IUPAC Term]
- amiloride hydrochloride [SNOMED Notion]
- n-amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride [Substance BNPC]
CISMeF manual mappings
- Amiloride adverse reaction (disorder) [SNOMED CT concept]
- Amiloride measurement (procedure) [SNOMED CT concept]
- amiloride [Substance BNPC]
Pharmacological action(s)
- acid sensing ion channel blockers [MeSH Descriptor]
- diuretics [MeSH Descriptor]
- epithelial sodium channel blockers [MeSH Descriptor]
Record concept(s)
- Amiloride Hydrochloride [MeSH concept]
- Amiloride Hydrochloride, Anhydrous [MeSH concept]
- amidal [MeSH concept]
- amiduret trom [MeSH concept]
- amiloberag [MeSH concept]
- amiloride [MeSH concept]
- kaluril [MeSH concept]
- midamor [MeSH concept]
- midoride [MeSH concept]
Related MeSH Supplementary Concept(s)
- 2',4'-dichlorobenzamil amiloride [MeSH Supplementary Concept]
- 2',4'-dimethylbenzamil [MeSH Supplementary Concept]
- 2'-methoxy-5'-nitrobenzamil [MeSH Supplementary Concept]
- 2-chlorobenzylamiloride [MeSH Supplementary Concept]
- 3',4'-dichlorobenzamil [MeSH Supplementary Concept]
- 3,5-diamino-6-fluoro-2-pyrazinoylguanidine [MeSH Supplementary Concept]
- 3,5-diamino-N-(aminoiminomethyl)-6-bromopyrazine-N-methylcarboxamide [MeSH Supplementary Concept]
- 4-(((((3,5-diamino-6-chloropyrazinyl)carbonyl)amino)iminomethyl)amino)-2,2,6,6-tetramethyl-1-piperidinyloxy [MeSH Supplementary Concept]
- 5,6-dichloroamiloride [MeSH Supplementary Concept]
- 5-(N,N-hexamethylene)amiloride [MeSH Supplementary Concept]
- 5-(N-2'-(4''-azidosalicylamidino)ethyl-N'-isopropyl)amiloride [MeSH Supplementary Concept]
- 5-(N-2'-aminoethyl-N'-isopropyl)amiloride-N-(4''-azidosalicylamide) [MeSH Supplementary Concept]
- 5-(N-4-chlorobenzyl)-N-(2',4'-dimethyl)benzamil [MeSH Supplementary Concept]
- 5-(N-butyl-N-methyl)amiloride [MeSH Supplementary Concept]
- 5-(N-ethyl-(2'-methoxy-5'-nitrobenzyl))amiloride [MeSH Supplementary Concept]
- 5-(N-methyl-N-(guanidinocarbonylmethyl))guanidine amiloride [MeSH Supplementary Concept]
- 5-(N-methyl-N-isobutyl)amiloride [MeSH Supplementary Concept]
- 5-(N-methyl-N-propyl)amiloride [MeSH Supplementary Concept]
- 5-(N-propyl-N-butyl)-2',4'-dichlorobenzamil amiloride [MeSH Supplementary Concept]
- 5-(N-tert-butyl)amiloride [MeSH Supplementary Concept]
- 5-(ethylpropyl)amiloride [MeSH Supplementary Concept]
- 5-N-(3-aminophenyl)amiloride [MeSH Supplementary Concept]
- 5-benzylglycinyl amiloride [MeSH Supplementary Concept]
- 5-diethylamiloride [MeSH Supplementary Concept]
- 5-dimethylamiloride [MeSH Supplementary Concept]
- 5H-amiloride [MeSH Supplementary Concept]
- 6-bromoamiloride [MeSH Supplementary Concept]
- 6-bromobenzamil [MeSH Supplementary Concept]
- 6-chloro-3,5-diaminopyrazine-3-carboxamide [MeSH Supplementary Concept]
- 6-iodoamiloride [MeSH Supplementary Concept]
- N(5)-piperazine-amiloride [MeSH Supplementary Concept]
- N(5)-piperidine-amiloride [MeSH Supplementary Concept]
- NVP-QBE170 [MeSH Supplementary Concept]
- alpha',2'-benzobenzamil [MeSH Supplementary Concept]
- amiloride caproate [MeSH Supplementary Concept]
- amiloride, bumetanide drug combination [MeSH Supplementary Concept]
- amiloride, hydrochlorothiazide drug combination [MeSH Supplementary Concept]
- benzamil [MeSH Supplementary Concept]
- esmalorid [MeSH Supplementary Concept]
- ethylisopropylamiloride [MeSH Supplementary Concept]
- frumil [MeSH Supplementary Concept]
- kalten [MeSH Supplementary Concept]
- lometazid [MeSH Supplementary Concept]
- methylisopropylamiloride [MeSH Supplementary Concept]
- moducrin [MeSH Supplementary Concept]
- phenylamil [MeSH Supplementary Concept]
- photoamiloride-1 [MeSH Supplementary Concept]
- uranidil A [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing amiloride (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amiloride [ICD-11 Extension code]
- Amiloride [NCIt concept]
- Amiloride (substance) [SNOMED CT concept]
- Product containing amiloride (medicinal product) [SNOMED CT concept]
- aMILoride [LOINC component]
- amiloride [ATC Code]
- amiloride [Substance BNPC]
- amiloride [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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