Wortmannin - CISMeF

Preferred Label : Wortmannin;

MeSH definition : An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.;

MeSH hyponym : MS-54; MS54;

MeSH CAS label : (1 alpha,11 alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione;

MeSH Related Number : 19545-26-7 (Wortmannin);

UNII : XVA4O219QW;

Details

Origin ID

D000077191;

UMLS CUI

C0078517;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Wortmannin [NCIt concept]
MeSH indexing information
- mycotoxins [MeSH Descriptor]
- phosphatidylinositol 3-Kinases [MeSH Descriptor]
Pharmacological action(s)
- antifungal agents [MeSH Descriptor]
- immunosuppressive agents [MeSH Descriptor]
- insulin antagonists [MeSH Descriptor]
- protein kinase inhibitors [MeSH Descriptor]
- radiation-sensitizing agents [MeSH Descriptor]
Record concept(s)
- MS 54 [MeSH concept]
- wortmannin [MeSH concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Wortmannin [NCIt concept]

Keyword's position in hierarchy(ies) :

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