Preferred Label : adenohypophyseal placode;
Uberon definition : The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives
rise to the endocrine secretory cells of the pituitary;
Uberon related term : pituitary placode;
Uberon Development note : Fate-mapping studies in amphibian, chick and mouse embryos (Eagleson et al., 1986;
1995; Couly and Le Douarin, 1985; Cobos et al., 2001; Osumi-Yamachita et al., 1994;
Kawamura et al., 2002) have shown that the cells contributing to the adenohypophysis
develop at the midline of the anterior neural ridge, which delineates the rostral
boundary of the neural plate, a region devoid of neural crest. The anterior neural
ridge also gives rise to the olfactory placodes and some forebrain tissues including
the olfactory bulbs (reviewed in Papalopulu, 1995). Ablation of this region in chick
embryos at the 2-4 somite stage confirmed these lineage analyses as it prevented formation
of Rathke's pouch and any further pituitary development (elAmraoui and Dubois, 1993).
Upon head folding, the oral ectoderm cells of the adenohypophyseal placode invaginate
towards the prospective ventral diencephalon to form Rathke's pouch, the anlage of
the adenohypophysis. Rathke's pouch starts as an invagination of the oral ectoderm
in response to inductive signals from the prospective diencephalon. The region of
the diencephalon above the pouch is known as the infundibulum and forms the posterior
lobe of the pituitary or neurohypohysis (Figure 3). While in most basal fish and tetrapods
the adenohypophyseal anlagen invaginates to form Rathke's pouch, in teleost fish the
adenohypophyseal placode does not invaginate but rather maintains its initial organization
forming a solid structure in the head (reviewed in Pogoda and Hammerschmidt; 2009);
Origin ID : 0009122;
Currated CISMeF NLP mapping
- Validated automatic mappings to NTBT
- develops from
- develops into
The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives
rise to the endocrine secretory cells of the pituitary
