" /> ETV6/NTRK3 Fusion Gene - CISMeF





Preferred Label : ETV6/NTRK3 Fusion Gene;

NCIt synonyms : NTRK3/ETV6 Fusion Gene; ETV6-NTRK3 Fusion Gene; ETV6::NTRK3 Fusion Gene;

NCIt related terms : ETV6-NTRK3;

NCIt definition : A fusion gene that results from a chromosomal translocation t(12;15)(p13;q25) which fuses the 5' half of the ETV6 gene to the 3' half of the NTRK3 gene. This fusion is associated with congenital fibrosarcoma, congenital mesoblastic nephroma (cellular and mixed variants), and secretory ductal carcinoma of breast.;

NCIt note : The presence of the ETV6-NTRK3 gene fusion in both congenital fibrosarcoma and cellular congenital mesoblastic nephroma indicate an excellent prognosis when compared to their histologically similar and more aggressive counterparts that do not have the fusion gene. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

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15/05/2024


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