Beclin-1 - CISMeF

Preferred Label : Beclin-1;

NCIt synonyms : GT197; Coiled-Coil Myosin-Like BCL2-Interacting Protein; Protein GT197; Beclin1; Testis Secretory Sperm-Binding Protein Li 215e; ATG6 Autophagy Related 6 Homolog; BECN1;

NCIt related terms : beclin 1;

NCIt definition : Beclin-1 (450 aa, 52 kDa) is encoded by the human BECN1 gene. This protein is involved in autophagy, apoptosis and host defense.;

Alternative definition : NCI-GLOSS: A protein involved in autophagy (the process by which a cell destroys proteins and other substances in its cytoplasm). Beclin 1 is found at lower levels in several types of cancer cells than in normal cells. It is a type of tumor suppressor.;

Codes from synonyms : CDR0000561320;

Details

Origin ID

C94671;

UMLS CUI

C1453431;

OMIM relation
- Beclin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- BECN1 protein, human [MeSH concept]
- BECN1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BECN1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Autophagy Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Apoptosis [NCIt concept]
- Autophagy [NCIt concept]
- Host Defense Mechanism [NCIt concept]

Keyword's position in hierarchy(ies) :

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