Activation of Membrane Attack Complex

Preferred Label : Activation of Membrane Attack Complex;

NCIt definition : A series of reactions that result in formation of a pore, composed of complement proteins C5b, C6, C7, C8, and C9, in the membrane of a pathogenic cell. The pore allows free diffusion of molecules into and out of the cell and reduces cell viability.;

NCI Metathesaurus CUI : CL449111;

Details

Origin ID

C92160;

UMLS CUI

C1523361;

Currated CISMeF NLP mapping
- activation of membrane attack complex [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- activation of membrane attack complex [GO term]
biological_process_has_initiator_chemical_or_drug
- Antigen [NCIt concept]
biological_process_involves_gene_product
- Complement Component C6 [NCIt concept]
- Complement Component C8 [NCIt concept]
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
- Complement Component C9 [NCIt concept]
biological_process_is_part_of_process
- Host Defense Mechanism [NCIt concept]
- Immunity [NCIt concept]
process_involves_gene
- C6 Gene [NCIt concept]
- C6 wt Allele [NCIt concept]
- C8A Gene [NCIt concept]
- C8A wt Allele [NCIt concept]
- C8B Gene [NCIt concept]
- C8B wt Allele [NCIt concept]
- C8G Gene [NCIt concept]
- C8G wt Allele [NCIt concept]
- C9 Gene [NCIt concept]
- C9 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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