Preferred Label : B Lymphocyte Cell Surface Molecule Pathway;
NCIt related terms : B Lymphocyte Cell Surface Molecules;
Alternative definition : BIOCARTA: B cells must communicate with their environment to participate in the immune
system as the source of antigen-specific immunoglobulins. Cell surface proteins on
B cells receive signals from the exterior, adhere to other cells, and transmit signals
to other cells. Antigen recognized by a B cell's immunoglobulin is presented in MHC
Class II to T cells during B cell activation. Cell surface immunoglobulins are a key
to B cell function, assisting in the response of B cells to specific antigen recognized
by that cell's immunoglobulin. CD54 (ICAM-1) is an adhesion molecule involved in the
binding of B cells to other cell types and LFA-1 is an integrin adhesion protein with
two subunits that binds to ICAM. CD35 and CD21 are receptors for complement factors
that stimulate the B cell response when complement is activated. CD80 and CD40 bind
to T cell proteins (CD28 and CD40L, respectively) to provide costimulatory signals
in the B cell-T cell interaction required for B cell activation. CD45 is a protein
tyrosine phosphatase that regulates activation of B cells and T cells through dephosphorylation
of signaling factors. CD32 is a receptor for IgG Fc, and is also called Fc gamma RII.
The number of proteins on the surface of B cell proteins indicates the complexity
of regulation of B cell activation. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_blymphocytePathway;
Origin ID : C91310;
UMLS CUI : C2984151;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
