Dipeptidyl Peptidase 4

Preferred Label : Dipeptidyl Peptidase 4;

NCIt synonyms : TP103; ADCP-2; Adenosine Deaminase Complexing Protein 2; T-Cell Activation Antigen CD26; CD26; Dipeptidyl Peptidase IV; CD26 Antigen; DPP IV; EC 3.4.14.5; ADABP; Dipeptidyl-Peptidase 4; Dipeptidyl-Peptidase IV; DPP4;

NCIt definition : Dipeptidyl peptidase 4 (766 aa, 88 kDa) is encoded by the human DPP4 gene. This protein is involved in proteolytic regulation of T cell activation.;

NCIt note : Dipeptidyl peptidase 4 soluble form can be both a diagnostic and prognostic marker of colon cancer. (UniProt); Dipeptidyl peptidase 4 is an enzyme that is a type II membrane protein that can undergo proteolysis to release a soluble, extracellular enzyme.;

Details

Origin ID

C91300;

UMLS CUI

C1447020;

Currated CISMeF NLP mapping
- Dipeptidyl peptidase IV (substance) [SNOMED CT concept]
- dipeptidyl peptidase 4 [MeSH Descriptor]
- dipeptidyl peptidase 4 [MeSH concept]
- dipeptidyl peptidase iv [SNOMED Notion]
OMIM relation
- Dipeptidyl peptidase iv [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DPP4 protein, human [MeSH concept]
- DPP4 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- DPP4 protein, human [MeSH concept]
- DPP4 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- DPP4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Cell Adhesion Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Begelomab [NCIt concept]
- Sitagliptin [NCIt concept]
- Sitagliptin Phosphate [NCIt concept]
- Talabostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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