Isocitrate Dehydrogenase [NADP], Mitochondrial

Preferred Label : Isocitrate Dehydrogenase [NADP], Mitochondrial;

NCIt synonyms : Oxalosuccinate Decarboxylase; EC 1.1.1.42; IDP; NADP ( )-Specific ICDH; ICD-M; IDH2; Isocitrate Dehydrogenase 2 (NADP ) Mitochondrial;

NCIt definition : Isocitrate dehydrogenase [NADP], mitochondrial protein (452 aa, 51 kDa) is encoded by the human IDH2 gene. This protein plays a role in intermediary metabolism.;

Details

Origin ID

C84990;

UMLS CUI

C2714104;

OMIM relation
- Isocitrate dehydrogenase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- IDH2 protein, human [MeSH concept]
- IDH2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- IDH2 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_gene_product_variant
- IDH2 NP_002159.2:p.R140G [NCIt concept]
- IDH2 NP_002159.2:p.R140L [NCIt concept]
- IDH2 NP_002159.2:p.R140Q [NCIt concept]
- IDH2 NP_002159.2:p.R140W [NCIt concept]
- IDH2 NP_002159.2:p.R140X [NCIt concept]
- IDH2 NP_002159.2:p.R172G [NCIt concept]
- IDH2 NP_002159.2:p.R172K [NCIt concept]
- IDH2 NP_002159.2:p.R172M [NCIt concept]
- IDH2 NP_002159.2:p.R172S [NCIt concept]
- IDH2 NP_002159.2:p.R172W [NCIt concept]
- IDH2 NP_002159.2:p.R172X [NCIt concept]
- IDH2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Enasidenib [NCIt concept]
- Enasidenib Mesylate [NCIt concept]
- IDH1/IDH2 Dual Inhibitor HMPL-306 [NCIt concept]
- Vorasidenib [NCIt concept]

Keyword's position in hierarchy(ies) :

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