" /> Enasidenib - CISMeF





Preferred Label : Enasidenib;

NCIt synonyms : CC-90007 Free Base;

NCIt definition : An orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, enasidenib specifically inhibits various mutant forms of IDH2, including the IDH2 variants R140Q, R172S, and R172K, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.;

UNII : 3T1SS4E7AG;

InChIKey : DYLUUSLLRIQKOE-UHFFFAOYSA-N;

CAS number : 1446502-11-9;

Molecule name : AG-221; AG 221;

Codes from synonyms : 182;

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Keyword's position in hierarchy(ies) : arborescence

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31/05/2025


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