Toxic Epidermal Necrolysis

Preferred Label : Toxic Epidermal Necrolysis;

NCIt synonyms : Lyell Syndrome; TEN;

NCIt related terms : Lyell's Syndrome;

NCIt definition : A systemic, serious, and life-threatening disorder characterized by erythematous and necrotic lesions in the skin and mucous membranes that are associated with bullous detachment of the epidermis. The epidermal and mucous membranes detachment leads to sepsis and may be fatal. The lesions appear throughout the body and occupy more than 30% of the body surfaces. It is a hypersensitivity reaction usually caused by drugs (e.g., sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and antiretroviral drugs).;

Alternative definition : NICHD: Drug-induced rapidly evolving cutaneous reaction resulting in areas of painful skin sloughing of greater than 30% body surface area.; CTCAE: A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.;

Codes from synonyms : E13743;

Details

Origin ID

C79777;

UMLS CUI

C0014518;

Automatic exact mappings (from CISMeF team)
- Thymic epithelial neoplasm [ORDO Disease]
- skin disease other [ICPC-2 Rubric]
- stevens-johnson syndrome [MeSH Descriptor]
Currated CISMeF NLP mapping
- LYELL SYNDROME [WHO-ART Included Term]
- Lyell syndrome [PASCAL descriptor]
- Lyell syndrome [MedDRA LLT]
- Lyell syndrome (disorder) [SNOMED CT concept]
- Lyell's syndrome [MedDRA LLT]
- Lyell's toxic epidermal necrolysis, subepidermal type (disorder) [Inactive SNOMED CT concept]
- Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum [ORDO Disease]
- Toxic epidermal necrolysis [ICD-11 Subcategory]
- Toxic epidermal necrolysis [ICD-9 code]
- Toxic epidermal necrolysis [MedDRA Preferred Term]
- Toxic epidermal necrolysis [ORDO Disease]
- epidermal necrolysis, toxic [MeSH concept]
- lyell's toxic epidermal necrolysis, subepidermal type [SNOMED Notion]
- toxic epidermal necrolysis [Disease (Nov.)]
DO Cross reference
- Stevens-Johnson syndrome [DO Concept]
False automatic mappings
- 10 (qualifier value) [SNOMED CT concept]
- Necrolysis epidermal toxic (Lyell type) [MedDRA LLT]
- TEN [MedDRA LLT]
- ten [SNOMED Notion]
Has associated anatomic sites
- Integumentary System [NCIt concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- LYELL SYNDROME [WHO-ART Included Term]
- Lyell syndrome [MedDRA LLT]
- Lyell syndrome (disorder) [SNOMED CT concept]
- Lyell's disease [MedDRA LLT]
- Lyell's syndrome [MedDRA LLT]
- Lyell's toxic epidermal necrolysis, subepidermal type (disorder) [Inactive SNOMED CT concept]
- Necrolysis epidermal toxic (Lyell type) [MedDRA LLT]
- Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum [ORDO Disease]
- TEN [MedDRA LLT]
- Toxic epidermal necrolysis [MedDRA Preferred Term]
- Toxic epidermal necrolysis [ORDO Disease]
- Toxic epidermal necrolysis [ICD-9 code]
- Toxic epidermal necrolysis [Lyell] [ICD-10 Sub-category]
- epidermal necrolysis, toxic [MeSH concept]
- lyell's toxic epidermal necrolysis, subepidermal type [SNOMED Notion]
- toxic epidermal necrolysis [Disease (Nov.)]
concept_is_in_subset
- CTCAE Adverse Events Version 4.0 Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Adverse Events Terminology [NCIt concept]
- Pediatric Adverse Events Terminology Mapped to MedDRA [NCIt concept]
disease_has_finding
- Cutaneous Involvement [NCIt concept]
disease_has_primary_anatomic_site
- Skin [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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