" /> Losartan - CISMeF





Preferred Label : Losartan;

NCIt synonyms : 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol;

NCIt definition : A non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle.;

Alternative definition : NCI-GLOSS: A drug used to treat high blood pressure. Losartan blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist.;

UNII : JMS50MPO89;

InChIKey : PSIFNNKUMBGKDQ-UHFFFAOYSA-N;

CAS number : 114798-26-4;

Chemical formula : C22H23ClN6O;

ChEBI ID : CHEBI:6541;

Codes from synonyms : CDR0000560966;

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29/05/2025


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