" /> Losartan Potassium - CISMeF





Preferred Label : Losartan Potassium;

NCIt synonyms : 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, Monopotassium Salt;

NCIt related terms : losartan; Cozaar;

NCIt definition : The potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.;

Alternative definition : NCI-GLOSS: A drug used to treat high blood pressure. Cozaar blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist.;

UNII : 3ST302B24A;

InChIKey : OXCMYAYHXIHQOA-UHFFFAOYSA-N;

CAS number : 124750-99-8;

Drug name : Cozaar;

Chemical formula : C22H22ClN6O.K;

Codes from synonyms : 31994; CDR0000560966; CDR0000589411; CDR0000589412;

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04/05/2025


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