Preferred Label : Montelukast;
NCIt definition : A selective cysteinyl leukotriene receptor antagonist with anti-inflammatory and bronchodilating
activities. Upon administration, montelukast selectively and competitively blocks
the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory
mediator leukotriene D4 (LTD4). Inhibition of LTD4 activity results in inhibition
of leukotriene-mediated inflammatory events including migration of eosinophils and
neutrophils, adhesion of leukocytes to vascular endothelium, monocyte and neutrophil
aggregation, increased airway edema, increased capillary permeability, and bronchoconstriction.
The CysLT1 receptor is found in a number of tissues including spleen, lung, placenta,
small intestine, and nasal mucosa, and in a variety of cell types including monocyte/macrophages,
mast cells, eosinophils, CD34-positive hemopoietic progenitor cells, neutrophils and
endothelial cells.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat symptoms of asthma, such
as trouble breathing, tight chest, wheezing, coughing, and runny nose. Montelukast
blocks the action of a substance that causes airways in the lungs to narrow and causes
other symptoms of asthma. It is a type of leukotriene receptor antagonist and a type
of antiasthmatic agent.;
UNII : MHM278SD3E;
InChIKey : UCHDWCPVSPXUMX-TZIWLTJVSA-N;
CAS number : 158966-92-8;
Chemical formula : C35H36ClNO3S;
ChEBI ID : CHEBI:50730;
Codes from synonyms : CDR0000601199; 340;
Origin ID : C66189;
UMLS CUI : C0298130;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
