Preferred Label : Montelukast Sodium;
NCIt synonyms : Cyclopropaneacetic Acid, 1-((((1R)-1-(3-((1E)-2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-,
Monosodium Salt;
NCIt related terms : Singulair;
NCIt definition : The orally bioavailable monosodium salt of montelukast, a selective cysteinyl leukotriene
receptor antagonist with anti-inflammatory and bronchodilating activities. Montelukast
selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor,
preventing binding of the inflammatory mediator leukotriene D4 (LTD4). Inhibition
of LTD4 activity results in inhibition of leukotriene-mediated inflammatory events
including: migration of eosinophils and neutrophils; adhesion of leukocytes to vascular
endothelium, monocyte and neutrophil aggregation; increased airway edema; increased
capillary permeability; and bronchoconstriction. The CysLT1 receptor is found in a
number of tissues including spleen, lung, placenta, small intestine, and nasal mucosa,
and in a variety of cell types including monocyte/macrophages, mast cells, eosinophils,
CD34-positive hemopoietic progenitor cells, neutrophils and endothelial cells.;
Alternative definition : NCI-GLOSS: A drug used to treat symptoms of asthma, such as trouble breathing, tight
chest, wheezing, coughing, and runny nose. Montelukast sodium blocks the action of
a substance that causes airways in the lungs to narrow and causes other symptoms of
asthma. It is a type of leukotriene receptor antagonist and a type of antiasthmatic
agent.;
UNII : U1O3J18SFL;
InChIKey : LBFBRXGCXUHRJY-HKHDRNBDSA-M;
CAS number : 151767-02-1;
Drug name : Singulair; Plenair; Montair;
Molecule name : MK 476;
Chemical formula : C35H35ClNO3S.Na;
ChEBI ID : CHEBI:6993;
Codes from synonyms : CDR0000600448; CDR0000600449;
Origin ID : C47625;
UMLS CUI : C0380447;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
