Preferred Label : Tenifatecan;
NCIt synonyms : Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin; (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-
9-yl (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl
Butanedioate;
NCIt definition : A highly lipophilic preparation of 7-Ethyl-10-hydroxycamptothecin (SN-38) with potential
antineoplastic activity. SN2310 is an oil-in-water emulsion of tocopherol covalently
linked, via a succinate linker, to SN-38, a synthetic derivative of the cytotoxic
alkaloid camptothecin. After succinate linker is hydrolyzed in vivo, the active moiety
SN-38 is released and selectively stabilizes topoisomerase I-DNA covalent complexes,
thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks
and inducing lethal double-stranded DNA breaks. This inhibits DNA replication and
triggers programmed cell death. SN2310 emulsion provides longer circulation time and
potentiates drug exposure as compared to the unconjugated SN-38.;
UNII : 7G0Y719Q80;
InChIKey : KRHZRBUSQSYTTP-PTXGIJCNSA-N;
CAS number : 850728-18-6;
Molecule name : SN-2310;
Chemical formula : C55H72N2O9;
Origin ID : C64772;
UMLS CUI : C1883354;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
