GATOR Complex Protein NPRL2

Preferred Label : GATOR Complex Protein NPRL2;

NCIt synonyms : NPR2-like; Nitrogen Permease Regulator 2-Like Protein; Tumor Suppressor Candidate 4; G21 Protein; NPR2-Like Protein; Tumor Suppressor Candidate 4 Protein; Gene 21 Protein;

NCIt definition : GATOR complex protein NPRL2 (380 aa, 44 kDa) is encoded by the human NPRL2 gene. This protein plays a role in the regulation of signaling.;

NCIt note : DEPDC5, NPRL2 and NPRL3 are subunits of the GATOR1 (GAP Activity TOward Rags 1) complex, which inhibits the amino acid-sensing branch of the mTORC1 pathway.;

Details

Origin ID

C63531;

UMLS CUI

C1883412;

OMIM relation
- Npr2-like protein, gator1 complex subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- NPRL2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Lysosome [NCIt concept]
gene_product_is_element_in_pathway
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Autophagy [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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